来自突尼斯的产OXA-58样碳青霉烯水解型青霉素酶OXA-97的耐碳青霉烯鲍曼不动杆菌分离株
Carbapenem-resistant Acinetobacter baumannii isolates from Tunisia producing the OXA-58-like carbapenem-hydrolyzing oxacillinase OXA-97.
作者信息
Poirel Laurent, Mansour Wejdene, Bouallegue Olfa, Nordmann Patrice
机构信息
Service de Bactériologie-Virologie, INSERM U914, Emerging Resistance to Antibiotics, Hôpital de Bicêtre, Assistance Publique/Hôpitaux de Paris, Faculté de Médecine et Université Paris Paris-Sud, K.-Bicêtre 94275, France.
出版信息
Antimicrob Agents Chemother. 2008 May;52(5):1613-7. doi: 10.1128/AAC.00978-07. Epub 2008 Feb 25.
Abstract
The basis of the beta-lactam resistance of 39 multidrug-resistant Acinetobacter baumannii isolates recovered from hospitalized patients was studied. These isolates were collected from 2001 to 2005 at the Sahloul Hospital in Sousse, Tunisia. They belonged to two distinct clones. One clone that grouped 19 isolates produced a carbapenem-hydrolyzing oxacillinase, OXA-97, that differed from OXA-58 by a single amino acid substitution and conferred the same beta-lactam resistance profile as OXA-58. The bla(OXA-97) gene was located on plasmids that varied in size in 18 isolates and was chromosomally located in a single isolate. Cloning and sequencing identified genetic structures surrounding the bla(OXA-97) gene similar to those reported to be adjacent to the bla(OXA-58) gene. In addition, the novel ISAba8 element (which is of the IS21 family) was identified. This is the first report of the nosocomial spread of carbapenemase producers in A. baumannii isolates in Africa.
摘要
对从住院患者中分离出的39株多重耐药鲍曼不动杆菌的β-内酰胺耐药性基础进行了研究。这些菌株于2001年至2005年在突尼斯苏塞的萨胡勒医院收集。它们属于两个不同的克隆。一个包含19株菌株的克隆产生了一种碳青霉烯水解型苯唑西林酶OXA-97，它与OXA-58仅在一个氨基酸上存在差异，并且具有与OXA-58相同的β-内酰胺耐药谱。bla(OXA-97)基因位于18株菌株中大小各异的质粒上，在一株菌株中位于染色体上。克隆和测序确定了bla(OXA-97)基因周围的遗传结构，与报道的紧邻bla(OXA-58)基因的结构相似。此外，还鉴定出了新型ISAba8元件（属于IS21家族）。这是非洲鲍曼不动杆菌分离株中碳青霉烯酶产生菌医院内传播的首次报道。
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