Patten S B
University of Calgary, Alberta.
Can J Psychiatry. 1990 Apr;35(3):257-9. doi: 10.1177/070674379003500312.
The relationship between propranolol and depression is a subject of controversy. Numerous case reports suggest that propranolol can cause depression, but two small prospective trials have failed to confirm this. The contemporary psychiatric literature is divided as to whether propranolol can cause depression. This study addresses this issue by re-analyzing side effect data from clinical trials of propranolol as an antihypertensive agent. A literature review was carried out and the data were analyzed using meta-analytic statistical techniques. Propranolol was found to cause depression as a side effect with a statistically greater frequency than the control medications used in these trials. As other side effects of propranolol include fatigue, diminished energy, decreased libido, anorexia and poor concentration, it is suggested that propranolol is a cause of organic mood disorder, depressed type.
普萘洛尔与抑郁症之间的关系是一个存在争议的话题。大量病例报告表明普萘洛尔可导致抑郁症，但两项小型前瞻性试验未能证实这一点。当代精神病学文献对于普萘洛尔是否会导致抑郁症存在分歧。本研究通过重新分析普萘洛尔作为抗高血压药物的临床试验中的副作用数据来解决这一问题。进行了文献综述，并使用荟萃分析统计技术对数据进行了分析。结果发现，普萘洛尔导致抑郁症作为副作用的发生频率在统计学上高于这些试验中使用的对照药物。由于普萘洛尔的其他副作用包括疲劳、精力减退、性欲降低、厌食和注意力不集中，因此有人认为普萘洛尔是器质性心境障碍（抑郁型）的一个病因。
