Department of Radiology, University of Washington, Seattle, WA, USA.
J Autism Dev Disord. 2012 Jan;42(1):105-15. doi: 10.1007/s10803-011-1216-y.
Brain mitochondrial dysfunction has been proposed as an etiologic factor in autism spectrum disorder (ASD). Proton magnetic resonance spectroscopic imaging ((1)HMRS) and MRI were used to assess for evidence of brain mitochondrial dysfunction in longitudinal samples of children with ASD or developmental delay (DD), and cross-sectionally in typically developing (TD) children at 3-4, 6-7 and 9-10 years-of-age. A total of 239 studies from 130 unique participants (54ASD, 22DD, 54TD) were acquired. (1)HMRS and MRI revealed no evidence for brain mitochondrial dysfunction in the children with ASD. Findings do not support a substantive role for brain mitochondrial abnormalities in the etiology or symptom expression of ASD, nor the widespread use of hyperbaric oxygen treatment that has been advocated on the basis of this proposed relationship.
脑线粒体功能障碍被认为是自闭症谱系障碍 (ASD) 的病因之一。质子磁共振波谱成像 ((1)HMRS) 和 MRI 用于评估自闭症谱系障碍或发育迟缓 (DD) 儿童的纵向样本以及 3-4、6-7 和 9-10 岁典型发育 (TD) 儿童的横断面样本中是否存在脑线粒体功能障碍的证据。共获得了来自 130 名独特参与者的 239 项研究 (54 名 ASD、22 名 DD、54 名 TD)。(1)HMRS 和 MRI 未发现 ASD 儿童存在脑线粒体功能障碍的证据。研究结果不支持脑线粒体异常在 ASD 的病因或症状表达中起重要作用，也不支持基于这种假设关系而提倡的高压氧治疗的广泛应用。
