Department of Neurology, Columbia University Medical Center, 180 Ft. Washington Avenue, Fifth Floor, New York, New York 10032, USA.
Muscle Nerve. 2011 Apr;43(4):485-8. doi: 10.1002/mus.21917.
Impaired mobility and fatigue are common in ambulatory spinal muscular atrophy (SMA) patients. The 6-minute walk test (6MWT) is a reliable measure of fatigue in SMA patients. To further evaluate fatigue, we used quantitative gait analysis during the 6MWT.
Nine subjects with SMA and 9 age- and gender-matched, healthy controls were evaluated. Gait parameters of speed and dynamic balance were correlated with 6MWT distance. Performance during the first and last 25 meters of the 6MWT was compared.
Speed-related gait parameters and support base correlated with 6MWT distance. Walking performance was worse for SMA patients. The deterioration in stride length during the 6MWT was greater in SMA patients than in controls.
Gait analysis detects fatigue, and the decrement in stride length may reflect selective muscle involvement in SMA. Further understanding of the mechanisms underlying fatigue may suggest additional targets for future therapeutic interventions.
行动不便和疲劳是脊髓性肌萎缩症（SMA）患者常见的问题。6 分钟步行测试（6MWT）是一种可靠的 SMA 患者疲劳评估方法。为了进一步评估疲劳，我们在 6MWT 期间使用定量步态分析。
评估了 9 名 SMA 患者和 9 名年龄和性别匹配的健康对照者。速度和动态平衡的步态参数与 6MWT 距离相关。比较了 6MWT 前 25 米和后 25 米的表现。
与速度相关的步态参数和支撑基础与 6MWT 距离相关。SMA 患者的行走表现更差。与对照组相比，SMA 患者在 6MWT 期间步长的恶化更为明显。
步态分析可检测疲劳，步长的减少可能反映 SMA 中肌肉的选择性受累。进一步了解疲劳的机制可能为未来的治疗干预提供更多的靶点。
