Montes Jacqueline, Zanotto Damiano, Dunaway Young Sally, Salazar Rachel, De Vivo Darryl C, Agrawal Sunil
SMA Clinical Research Center, Department of Neurology, Columbia University Medical Center, 180 Fort Washington Avenue, 5th Floor, New York, New York, 10032, USA.
Department of Rehabilitation and Regenerative Medicine, Columbia University, New York, New York, USA.
Muscle Nerve. 2017 Aug;56(2):230-236. doi: 10.1002/mus.25484. Epub 2017 Feb 15.
Gait impairment is common in spinal muscular atrophy (SMA) and is described using clinical assessments and instrumented walkways. Continuous over-ground walking has not been studied.
Nine SMA participants completed the 6-minute walk test (6MWT) and 10-meter walk/run wearing instrumented footwear (SoleSound). Data were simultaneously collected using a reference system (GAITRite). The root-mean-square error (RMSE) indicated criterion validity. The decrease in walking speed represented fatigue. Foot loading patterns were evaluated using force sensors.
The RMSE for stride time, length, and velocity ranged from 1.3% to 1.7%. Fatigue was 11.6 ± 9.1%, which corresponded to an average deceleration of 0.37 ± 0.28 mm/s . Participants spent most of their stance without heel contact. Forefoot contact occurred early in the gait cycle.
These results suggest that footwear-based devices are an alternative to specialized equipment for gait assessment. Better understanding of gait disturbances should inform ongoing treatment efforts and provide a more sensitive outcome measure. Muscle Nerve 56: 230-236, 2017.
步态障碍在脊髓性肌萎缩症（SMA）中很常见，通常通过临床评估和仪器化步道进行描述。尚未对连续的地面行走进行研究。
九名SMA参与者完成了6分钟步行测试（6MWT）以及穿着仪器化鞋具（SoleSound）进行的10米步行/跑步测试。使用参考系统（GAITRite）同时收集数据。均方根误差（RMSE）表明了标准效度。步行速度的下降代表疲劳。使用力传感器评估足部负荷模式。
步幅时间、步幅长度和步幅速度的RMSE范围为1.3%至1.7%。疲劳程度为11.6±9.1%，这对应于平均减速0.37±0.28毫米/秒。参与者在站立期的大部分时间没有足跟接触。前脚掌接触发生在步态周期的早期。
这些结果表明，基于鞋具的设备是用于步态评估的专业设备的替代方案。对步态障碍的更好理解应为正在进行的治疗工作提供依据，并提供更敏感的结果指标。《肌肉与神经》56: 230 - 236, 2017年。
