Ability of Nicotinamide Riboside to Prevent Muscle Fatigue of Barrows Subjected to a Performance Test.

The objective of this study was to determine the daily dietary nicotinamide riboside (NR) dose required to maximize the delay of subjective muscle fatigue onset. Barrows ( = 100) were assigned to one of five treatments: a conventional swine finishing diet containing 0 (CON), 15 (15NR), 30 (30NR), 45 (45NR) mg·kg body weight·d NR, or CON supplemented with 45 mg·kg body weight·d NR by drench or cookie dough (DRE). All treatments were administered for the final 11 days of feeding. On supplementation d 10, barrows individually experienced a performance test at 1.09 m/s until they were subjectively exhausted. Wireless electromyography (EMG) sensors were affixed to the biceps femoris (BF), tensor fascia latae (TFL), and semitendinosus (ST) to measure real-time muscle activity. There were no treatment effects for barrow speed ( = 0.57), a tendency for a treatment effect ( = 0.07) for distance, and a treatment effect ( = 0.04) on time to exhaustion. Barrows of the 15NR and DRE treatments had greater ( = 0.05) distances to exhaustion than CON barrows but did not differ from other NR barrows ( > 0.11). Barrows in the 45NR treatment did not differ ( = 0.11) in distance from 30NR barrows but tended to have a greater ( = 0.07) distance compared to CON barrows. All other treatment comparisons did not differ ( > 0.27). Barrows in the DRE treatment moved for longer ( < 0.01) than CON barrows, but all other treatments did not differ from each other ( > 0.15). There was no treatment × period interaction for all muscles' root mean square (RMS) values ( > 0.16), but there were Period effects for all muscles ( < 0.01) and a Treatment effect ( = 0.04) in the TFL. For all muscles, period 4 had greater RMS values than all other periods ( < 0.01), who did not differ from each other ( 0.29). In the TFL, CON barrows had greater RMS values during the performance test compared to all NR treatments ( < 0.02), who did not differ from each other ( 0.18). Overall, NR demonstrates potential in being a useful tool in fatigue prevention, but efficient administration of the compound needs further investigation.