Dipartimento di Chimica Organica e Biochimica, Università di Napoli Federico II, Complesso Universitario Monte Sant'Angelo, via Cinthia, 4, I-80126 Napoli.
Chem Biodivers. 2011 Mar;8(3):373-413. doi: 10.1002/cbdv.201000303.
The study of the base-pairing properties of nucleic acids with sugar moieties in the backbone belonging to the L-series (β-L-DNA, β-L-RNA, and their analogs) are reviewed. The major structural factors underlying the formation of stable heterochiral complexes obtained by incorporation of modified nucleotides into natural duplexes, or by hybridization between homochiral strands of opposite sense of chirality are highlighted. In addition, the perspective use of L-nucleic acids as candidates for various therapeutic applications, or as tools for both synthetic biology and etiology-oriented investigations on the structure and stereochemistry of natural nucleic acids is discussed.
本文综述了糖基位于主链的 L 系列（β-L-DNA、β-L-RNA 及其类似物）核酸碱基配对性质的研究。重点介绍了通过将修饰的核苷酸掺入天然双链体中，或通过相反手性的同型链之间杂交形成稳定的异手性复合物的主要结构因素。此外，还讨论了 L-核酸作为各种治疗应用的候选物，或作为合成生物学和针对天然核酸结构和立体化学的病因导向研究的工具的潜在用途。
