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巴塔戈尼亚皂苷 B 和 C，两种来自海参 Psolus patagonicus 的抗真菌硫酸化三萜糖苷。

Patagonicosides B and C, two antifungal sulfated triterpene glycosides from the sea cucumber Psolus patagonicus.

机构信息

UMYMFOR (CONICET - UBA) and Departamento de Química Orgánica, Facultad de Ciencias Exactas y Naturales, Pabellón 2, Ciudad Universitaria, 1428 Buenos Aires, Argentina.

出版信息

Chem Biodivers. 2011 Mar;8(3):467-75. doi: 10.1002/cbdv.201000044.

DOI:10.1002/cbdv.201000044
PMID:21404430
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3889216/
Abstract

Two new triterpene glycosides, patagonicosides B and C (2 and 3, resp.), together with the known patagonicoside A (1), have been isolated from the EtOH extract of the sea cucumber Psolus patagonicus. The structures of the new compounds were established on the basis of extensive NMR spectroscopic analysis ((1)H- and (13)C-NMR, (1)H,(1)H-COSY, HMBC, HSQC, TOCSY, and NOESY), HR-ESI-MS data, and chemical transformations. Compounds 1-3 and their desulfated analogs showed antifungal activities against the phytopathogenic fungus Cladosporium cladosporoides in a dose-dependent fashion.

摘要

从海参 Psolus patagonicus 的乙醇提取物中分离得到了两种新的三萜糖苷，分别为 patagonicoside B 和 C（2 和 3），以及已知的 patagonicoside A（1）。新化合物的结构是基于广泛的 NMR 光谱分析（（1）H 和（13）C-NMR、（1）H，（1）H-COSY、HMBC、HSQC、TOCSY 和 NOESY）、HR-ESI-MS 数据和化学转化确定的。化合物 1-3 及其去硫酸化类似物表现出对植物病原菌炭疽病菌的抗真菌活性，呈剂量依赖性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/43ca/3889216/ae9c80582046/nihms493616f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/43ca/3889216/59f706f9166b/nihms493616f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/43ca/3889216/ed7c9360dcb8/nihms493616f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/43ca/3889216/ae9c80582046/nihms493616f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/43ca/3889216/59f706f9166b/nihms493616f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/43ca/3889216/ed7c9360dcb8/nihms493616f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/43ca/3889216/ae9c80582046/nihms493616f3.jpg

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