a UMYMFOR (CONICET - UBA), Departamento de Química Orgánica, Facultad de Ciencias Exactas y Naturales, Pabellón 2, Ciudad Universitaria , 1428 Buenos Aires , Argentina.
Nat Prod Res. 2014;28(4):213-20. doi: 10.1080/14786419.2012.751596. Epub 2012 Dec 17.
A new triterpene glycoside, pseudocnoside A (1), was isolated from the sea cucumber Pseudocnus dubiosus leoninus. The structure of the new compound was established on the basis of extensive NMR spectroscopic analysis ((1)H and (13)C NMR, (1)H,(1)H-COSY, HMBC, HSQC, TOCSY and NOESY), HR-ESI-MS data and chemical transformations. In addition, the cytotoxicity and antiproliferative activities of 1 and structurally related triterpene glycosides isolated from the sea cucumbers Psolus patagonicus and Hemioedema spectabilis were evaluated against cancer cell lines A-549 and HeLa.
从海参 Pseudocnus dubiosus leoninus 中分离得到一种新的三萜糖苷，伪诺苷 A（1）。根据广泛的 NMR 光谱分析（1H 和 13C NMR、1H,1H-COSY、HMBC、HSQC、TOCSY 和 NOESY）、高分辨电喷雾电离质谱（HR-ESI-MS）数据和化学转化，确定了新化合物的结构。此外，还评估了从海参 Psolus patagonicus 和 Hemioedema spectabilis 中分离得到的与 1 结构相关的三萜糖苷对肺癌细胞系 A-549 和宫颈癌细胞系 HeLa 的细胞毒性和增殖抑制活性。
