Avilov S A, Antonov A S, Drozdova O A, Kalinin V I, Kalinovsky A I, Stonik V A, Riguera R, Lenis L A, Jiménez C
Pacific Institute of Bioorganic Chemistry, the Far Eastern Division of the Russian Academy of Sciences, 690022, Vladivostok, Russian Federation.
J Nat Prod. 2000 Jan;63(1):65-71. doi: 10.1021/np9903447.
Three new monosulfated triterpene glycosides, calcigerosides B (2), C(1) (3), and C(2) (4), along with the known cucumarioside G(2) (1), have been isolated from the sea cucumber Pentamera calcigera. Their structures have been deduced from extensive spectral analysis (NMR and MS) and chemical evidence. Compounds 2-4 present a novel pentasacharide chain never reported before in sea cucumber triterpene glycosides. The desulfated derivatives of calcigerosides B, C(1), and C(2) (5, 7, and 9, respectively) showed moderate cytotoxicity (IC(50) = 5 microg/mL) against a selection of four human and mouse tumor cell lines.
从海参五角瓜参（Pentamera calcigera）中分离出了三种新的单硫酸化三萜糖苷，即钙生糖苷B（2）、C（1）（3）和C（2）（4），以及已知的海参苷G（2）（1）。它们的结构已通过广泛的光谱分析（核磁共振和质谱）及化学证据推导得出。化合物2 - 4具有一种新型的五糖链，这在海参三萜糖苷中从未有过报道。钙生糖苷B、C（1）和C（2）的脱硫酸衍生物（分别为5、7和9）对四种人类和小鼠肿瘤细胞系表现出中等程度的细胞毒性（IC50 = 5微克/毫升）。
