Marais B J, Schaaf H S, Donald P R
Department of Paediatrics and Child Health, Faculty of Health Sciences, Stellenbosch University, Tygerberg, South Africa.
Infect Disord Drug Targets. 2011 Apr;11(2):144-56. doi: 10.2174/187152611795589645.
Childhood tuberculosis (TB) continues to be a neglected disease in areas where limited resources restrict the focus of national TB control programmes to only the most infectious sputum smear-positive cases. However, appreciation that children contribute a significant proportion to the global TB disease burden and suffer severe TB-related morbidity and mortality is growing. The World Health Organization (WHO) published guidelines on the management of paediatric TB in 2006 and child friendly drug formulations have been made available to deserving nations via the Global Drug Facility (GDF) since 2008. These advances also served to emphasize the considerable programmatic barriers that remain in resource-limited settings. This review provides an overview of current treatment practices, presenting the authors personal perspectives on issues related to the treatment of childhood TB, together with a brief synopsis of potential future treatment options.
在资源有限、国家结核病控制规划仅将重点放在传染性最强的痰涂片阳性病例的地区，儿童结核病仍然是一种被忽视的疾病。然而，人们越来越认识到儿童在全球结核病疾病负担中占很大比例，并且遭受与结核病相关的严重发病和死亡。世界卫生组织（WHO）于2006年发布了儿童结核病管理指南，自2008年以来，通过全球药品设施（GDF）向有需要的国家提供了适合儿童使用的药物剂型。这些进展也凸显了资源有限环境中仍然存在的重大规划障碍。本综述概述了当前的治疗实践，阐述了作者对儿童结核病治疗相关问题的个人观点，并简要介绍了未来潜在的治疗选择。
