De Cock K M, Binkin N J, Zuber P L, Tappero J W, Castro K G
London School of Hygiene and Tropical Medicine, United Kingdom.
JAMA. 1996 Nov 13;276(18):1502-7. doi: 10.1001/jama.276.18.1502.
Each year, there are an estimated 8 million new cases of tuberculosis (TB) and 3 million deaths due to TB, most of which occur in resource-poor countries. Tuberculosis incidence is increasing rapidly in countries with high rates of human immunodeficiency virus (HIV) infection, and despite the availability of effective interventions, many TB programs are failing to cope with the increased TB caseload. This report highlights gaps in current understanding of the interaction between TB and HIV that contribute to failure of optimal TB management and control; we focus on the diagnosis of TB, its epidemiology and transmission, preventive strategies, and programmatic issues in the integration of HIV and TB services. Research into how best to apply existing knowledge will be at least as important as searching for new knowledge. The global control of TB will also require increased resources, greater political commitment, and stronger international public health leadership.
据估计，每年有800万新增结核病病例，并有300万人死于结核病，其中大部分发生在资源匮乏的国家。在人类免疫缺陷病毒（HIV）感染率高的国家，结核病发病率正在迅速上升，尽管有有效的干预措施，但许多结核病防治项目仍难以应对不断增加的结核病病例负担。本报告强调了目前对结核病与HIV相互作用的理解存在的差距，这些差距导致了最佳结核病管理和控制的失败；我们关注结核病的诊断、其流行病学和传播、预防策略以及HIV与结核病服务整合中的规划问题。研究如何最好地应用现有知识至少与寻求新知识同样重要。全球结核病控制还需要增加资源、加大政治承诺以及加强国际公共卫生领导。
