Mujugira Andrew, Magaret Amalia S, Baeten Jared M, Celum Connie, Lingappa Jairam
Department of Global Health, University of Washington, Seattle, WA, USA.
BMC Res Notes. 2011 Mar 15;4:64. doi: 10.1186/1756-0500-4-64.
Herpes simplex virus type 2 (HSV-2) is the most frequent cause of genital ulcer disease worldwide and has been associated with increased risk for HIV-1 acquisition and transmission. We conducted a cross-sectional analysis of risk factors for HSV-2 infection among HIV-1 uninfected partners, whose partners were co-infected with HIV-1 and HSV-2.
Between November 2004 and April 2007, 3408 HIV-discordant couples, in which the HIV-1 infected partners were HSV-2 seropositive with CD4 250 cells/mm3 or greater, were enrolled in an HSV-2 suppression trial to prevent HIV-1 transmission at 14 sites in 7 African countries. Clinical & behavioral data, HSV-2 and HIV-1 testing were conducted at enrolment. Univariate and multivariate Poisson regression analyses were performed separately, by gender of the HIV-1 infected partner.
Among 3354 HIV-1 uninfected participants, 32% were female and overall 71% were HSV-2 seropositive. Among couples with female HIV-1 infected partners, HIV-1 plasma RNA [aPR 1.03; 95% CI: 0.99 to 1.06; p = 0.11] and CD4 count [aPR 1.00; 95% CI: 0.98 to 1.01; p = 0.48] in the HSV-2/HIV-1 dually infected female and circumcision in the HIV-1 uninfected male partner [aPR 0.94; 95% CI: 0.88 to 1.00; p = 0.06] were not associated with reduced risk of HSV-2 seropositivity, after adjusting for other factors.
In this cross-sectional analysis of African HIV-1 serodiscordant heterosexual couples with prevalent HSV-2 infection in the HIV-1 infected partner, HIV-1 plasma RNA and CD4 count in the dually-infected partner and male circumcision in the HIV-1 uninfected partner were not associated with HSV-2 concordance.
ClinicalTrials.gov NCT00194519.
2型单纯疱疹病毒（HSV - 2）是全球生殖器溃疡疾病最常见的病因，并且与获得和传播HIV - 1的风险增加有关。我们对HIV - 1未感染伴侣中HSV - 2感染的危险因素进行了横断面分析，这些伴侣的另一方同时感染了HIV - 1和HSV - 2。
在2004年11月至2007年4月期间，3408对HIV血清学不一致的夫妇参与了一项HSV - 2抑制试验，以预防HIV - 1传播。这些夫妇中，HIV - 1感染的一方HSV - 2血清学呈阳性且CD4细胞计数为250个/mm³或更高，该试验在7个非洲国家的14个地点开展。在入组时进行了临床和行为数据收集、HSV - 2及HIV - 1检测。根据HIV - 1感染伴侣的性别分别进行单因素和多因素泊松回归分析。
在3354名HIV - 1未感染参与者中，32%为女性，总体上71%的人HSV - 2血清学呈阳性。在HIV - 1感染伴侣为女性的夫妇中，调整其他因素后，HSV - 2/HIV - 1双重感染女性体内的HIV - 1血浆RNA[调整后风险比（aPR）1.03；95%置信区间（CI）：0.99至1.06；p = 0.11]和CD4细胞计数[aPR 1.00；95% CI：0.98至1.01；p = 0.48]以及HIV - 1未感染男性伴侣的包皮环切术[aPR 0.94；95% CI：0.88至1.00；p = 0.06]与HSV - 2血清学阳性风险降低无关。
在这项对非洲HIV - 1血清学不一致的异性恋夫妇进行的横断面分析中，HIV - 1感染伴侣中普遍存在HSV - 2感染，双重感染伴侣的HIV - 1血浆RNA和CD4细胞计数以及HIV - 1未感染伴侣的包皮环切术与HSV - 2一致性无关。
ClinicalTrials.gov NCT00194519。
