Institute of Carbon Science and Technology, Shinshu University, Department of Orthopaedic Surgery, School of Medicine, 3-1-1 Asahi, Matsumoto, Nagano 390-8621, Japan.
J Proteomics. 2011 Nov 18;74(12):2703-12. doi: 10.1016/j.jprot.2011.03.004. Epub 2011 Mar 23.
Carbon nanotubes (CNTs) have already been successfully implemented in various fields, and they are anticipated to have innovative applications in medical science. However, CNTs have asbestos-like properties, such as their nanoscale size and high aspect ratio (>100). Moreover, CNTs may persist in the body for a long time. These properties are thought to cause malignant mesothelioma and lung cancer. However, based on conventional toxicity assessment systems, the carcinogenicity of asbestos and CNTs is unclear. The reason for late countermeasures against asbestos is that reliable, long-term safety assessments have not yet been developed by toxicologists. Therefore, a new type of long-term safety assessment, different from the existing methods, is needed for carbon nanomaterials. Recently, we applied a proteomic approach to the safety assessment of carbon nanomaterials. In this review, we discuss the basic concept of our approach, the results, the problems, and the possibility of a long-term safety assessment for carbon nanomaterials using the toxicoproteomic approach.
碳纳米管（CNTs）已经在各个领域得到了成功的应用，并且有望在医学领域有创新的应用。然而，CNTs 具有与石棉类似的特性，如纳米级尺寸和高纵横比（>100）。此外，CNTs 可能在体内长期存在。这些特性被认为会导致恶性间皮瘤和肺癌。然而，基于传统的毒性评估系统，石棉和 CNTs 的致癌性尚不清楚。对石棉采取迟来的对策的原因是，毒理学家尚未开发出可靠的、长期的安全评估方法。因此，需要一种不同于现有方法的新型碳纳米材料的长期安全评估方法。最近，我们将蛋白质组学方法应用于碳纳米材料的安全性评估。在这篇综述中，我们讨论了我们方法的基本概念、结果、问题以及使用毒理蛋白质组学方法对碳纳米材料进行长期安全性评估的可能性。
