Shiley-Marcos Alzheimer's Disease Research Center and the Department of Neurosciences, University of California, San Diego, CA, USA.
Am J Alzheimers Dis Other Demen. 2011 May;26(3):235-9. doi: 10.1177/1533317511402316. Epub 2011 Mar 15.
The Mild Cognitive Impairment Screen (MCIS) is a computer-based cognitive assessment designed for clinical and research use in detecting amnestic mild cognitive impairment (aMCI). Performance on the MCIS is reported as the Memory Performance Index (MPI). However, the comparability between the MPI and traditional neuropsychological tests in detecting aMCI, and in differentiating it from Alzheimer's disease (AD) and normal aging has not been examined. A cross-sectional study was conducted to assess the validity of the MPI relative to standard neuropsychological measures. Participants included 12 individuals diagnosed with aMCI, 49 with mild AD, and 25 healthy elderly. The MCIS significantly discriminated among aMCI, AD, and healthy elderly controls. The MCIS is effective in detecting aMCI, and in discriminating it from cognitive changes observed in AD and normal aging. The MCIS may be a valuable tool in the identification of elderly at high risk for dementia due to its ease-of-use and brief administration time.
轻度认知障碍筛查（MCIS）是一种基于计算机的认知评估工具，专为临床和研究使用而设计，用于检测遗忘型轻度认知障碍（aMCI）。MCIS 的表现报告为记忆表现指数（MPI）。然而，MPI 与传统神经心理学测试在检测 aMCI 以及区分 AD 和正常衰老方面的可比性尚未得到检验。一项横断面研究评估了 MPI 相对于标准神经心理学测量的有效性。参与者包括 12 名被诊断为 aMCI 的个体、49 名轻度 AD 患者和 25 名健康老年人。MCIS 可显著区分 aMCI、AD 和健康老年人对照组。MCIS 可有效检测 aMCI，并将其与 AD 和正常衰老中观察到的认知变化区分开来。由于其易于使用和简短的管理时间，MCIS 可能是识别因痴呆而处于高风险的老年人的有价值的工具。
