Macintyre E A, Salloum E, Sigaux F
Molecular Hematology Laboratory, Saint-Louis Hospital, Paris, France.
Nouv Rev Fr Hematol (1978). 1990;32(1):95-9.
Analysis of 267 consecutive cases of acute lymphoblastic leukemias (ALL) showed that 67 (25%) of cases were of T cell lineage and that 21/67 (31%) expressed the CD3 antigen. Of 13 CD3+ T-ALLs, 7 expressed gamma delta and 6 alpha beta. Comparison of these 2 groups showed differences in clinical and immunophenotypic parameters. The patterns of rearrangement of TCR gamma and TCR delta genes and their junctional nucleotide sequences also differed between the 2 groups. Further analysis of these patients may allow the distinction of subpopulations of ALL which merit altered management.
对267例连续性急性淋巴细胞白血病（ALL）病例的分析显示，67例（25%）为T细胞系，其中21/67例（31%）表达CD3抗原。在13例CD3+ T-ALL中，7例表达γδ，6例表达αβ。这两组病例在临床和免疫表型参数上存在差异。两组之间TCRγ和TCRδ基因的重排模式及其连接核苷酸序列也有所不同。对这些患者的进一步分析可能有助于区分ALL的亚群，这些亚群值得改变治疗方案。
