Departamento de Diagnóstico Oral, Faculdade de Odontologia de Piracicaba, FOP/UNICAMP Universidade Estadual de Campinas, Piracicaba, SP, Brazil.
Mycopathologia. 2011 Aug;172(2):117-24. doi: 10.1007/s11046-011-9404-z. Epub 2011 Mar 16.
Proteinases produced by Candida albicans are one kind of virulence factor expressed that contribute to adherence and invasion of host tissue. Proteinase inhibitor of human immunodeficiency virus in experimental candidiasis suggested reduction in fungal infection, and medicinal plants could be a source of alternative agent to prevent diseases. In this study, we investigated the production of proteinases by C. albicans from clinical isolates and the action of plant extracts against strains of C. albicans and its synthesized proteinases, comparing with antifungal fluconazole and amphotericin B and proteinase inhibitors pepstatin A, amprenavir, and ritonavir. The results reported here showed that these extracts have a certain kind of action and that the search for new antifungal agents could be found at the plants.
白色念珠菌产生的蛋白酶是其表达的一种毒力因子，有助于其黏附和侵袭宿主组织。在实验性念珠菌病中，人类免疫缺陷病毒的蛋白酶抑制剂可减少真菌感染，药用植物可能是预防疾病的替代药物的来源。在这项研究中，我们研究了来自临床分离株的白色念珠菌产生蛋白酶的情况，以及植物提取物对白色念珠菌及其合成蛋白酶的作用，并与抗真菌药物氟康唑、两性霉素 B 和蛋白酶抑制剂胃蛋白酶抑制剂 A、氨普那韦和利托那韦进行了比较。这里报道的结果表明，这些提取物具有一定的作用，并且可以在植物中寻找新的抗真菌药物。
