Costa Carolina Rodrigues, de Lemos Janine Aquino, Passos Xisto Sena, de Araújo Crystiane Rodrigues, Cohen Ana Joaquina, Souza Lúcia Kioko Hasimoto E, Silva Maria do Rosário Rodrigues
Instituto de Patologia Tropical e Saúde Pública da, Universidade Federal de Goiás, Goiás, Brazil.
Mycopathologia. 2006 Jul;162(1):45-50. doi: 10.1007/s11046-006-0032-y.
In this study, we investigated the yeasts colonization of genus Candida, including C. dubliniensis, isolated of HIV-infected patients oral cavities and we accessed in vitro susceptibility pattern of the Candida isolates to four antifungal agents. Out of 99 patients investigated, 62 (62.6%) were colonized with yeasts. C. albicans was the prevailing species (50%). C. dubliniensis isolates were not recovered in our study. We verified that 8.1% of the yeasts isolated were resistant to fluconazole, 8.1% to itraconazole and 3.2% to voriconazole. The isolates demonstrated very low voriconazole MICs, in which 79% (49/62) presented values of 0.015 mug/ml. All Candida isolates were susceptible to amphotericin B. The results reported here showed that although C. albicans continues to be present in one-half of oral Candida carriage of HIV-infected patients, Candida non-albicans species are increasing among these patients. Besides, the findings of resistant isolates endorse the role of antifungal susceptibility testing whenever antifungal treatment with azoles is planned.
在本研究中，我们调查了念珠菌属酵母菌的定植情况，包括从HIV感染患者口腔中分离出的都柏林念珠菌，并评估了念珠菌分离株对四种抗真菌药物的体外药敏模式。在99名接受调查的患者中，62名（62.6%）有酵母菌定植。白色念珠菌是主要菌种（50%）。在我们的研究中未分离到都柏林念珠菌。我们证实，分离出的酵母菌中有8.1%对氟康唑耐药，8.1%对伊曲康唑耐药，3.2%对伏立康唑耐药。分离株的伏立康唑最低抑菌浓度非常低，其中79%（49/62）的值为0.015μg/ml。所有念珠菌分离株对两性霉素B敏感。此处报告的结果表明，尽管白色念珠菌在HIV感染患者口腔念珠菌定植中仍占一半，但非白色念珠菌在这些患者中正在增加。此外，耐药分离株的发现支持了在计划使用唑类抗真菌药物治疗时进行抗真菌药敏试验的作用。
