School of Life Science, Northeast Agricultural University, Harbin 150030, China.
Bioorg Med Chem Lett. 2011 Apr 15;21(8):2313-5. doi: 10.1016/j.bmcl.2011.02.095. Epub 2011 Mar 14.
A new quinoline derivative, methyl 8-(3-methoxy-3-methylbutyl)-2-methylquinoline-4-carboxylate (1), was isolated from the endophytic strain Streptomyces sp. neau50, and the structure was elucidated by extensive spectroscopic analysis. Compound 1 showed cytotoxicity against human lung adenocarcinoma cell line A549 with an IC(50) value of 29.3 μg mL(-1).
从内生菌株链霉菌属 neau50 中分离得到一种新的喹啉衍生物，甲基 8-(3-甲氧基-3-甲基丁基)-2-甲基喹啉-4-羧酸酯（1），通过广泛的光谱分析阐明了其结构。化合物 1 对人肺腺癌细胞系 A549 表现出细胞毒性，IC50值为 29.3 μg mL-1。
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