叛乱还是审查：NK 细胞在 HIV-1 感染中对 DC 功能的调节。
Mutiny or scrutiny: NK cell modulation of DC function in HIV-1 infection.
机构信息
Ragon Institute of MGH, MIT, and Harvard, Massachusetts General Hospital, Charlestown, MA 02120, USA.
出版信息
Trends Immunol. 2011 May;32(5):219-24. doi: 10.1016/j.it.2011.02.003. Epub 2011 Mar 14.
Abstract
Accumulating data suggest that natural killer (NK) cells are involved not only in the innate antiviral response following infection, but also in shaping the quality of the adaptive immune response by modulating the functional properties of myeloid dendritic cells (DC) during the acute immune response to infection. In this role, NK cells ensure that only fully mature, immunogenic DCs gain access to inductive sites, where they might prime effective antiviral adaptive immune responses. However, increasing evidence now suggests that several aspects of this cross-talk between NK cells and DCs are compromised during HIV infection, potentially contributing to immune dysfunction.
摘要
越来越多的数据表明，自然杀伤 (NK) 细胞不仅参与感染后先天抗病毒反应，而且通过在感染急性免疫反应期间调节髓样树突状细胞 (DC) 的功能特性，影响适应性免疫反应的质量。在这一作用中，NK 细胞确保只有完全成熟、具有免疫原性的 DC 才能进入诱导部位，在那里它们可以引发有效的抗病毒适应性免疫反应。然而，越来越多的证据表明，在 HIV 感染过程中，NK 细胞和 DC 之间的这种串扰的几个方面受到了损害，这可能导致免疫功能障碍。
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