Department of Frontier Materials, Graduate School of Engineering, Nagoya Institute of Technology, Gokiso-cho, Showa-ku, Nagoya 466-8555, Japan.
Dent Mater J. 2011;30(2):232-8. doi: 10.4012/dmj.2010-141. Epub 2011 Mar 10.
Two types of nonwoven fabric, consisting of siloxane-doped vaterite (SiV) and poly(lactic acid) (PLA), for guided bone regeneration (GBR) were prepared by an electrospinning. One of the fabrics, SiV-PLA(M), was derived from PLA mixed with the solution of SiV dispersed in chloroform. Another one, SiV-PLA(K), was derived from a composite prepared by kneading SiV and PLA while heating at 200°C. The SiV-PLA(K) fabric shows higher degradability in dilute NaOH aq. than the SiV-PLA(M) fabric. To improve the cellular compatibility of the fabric, the fibers were coated with hydroxyapatite (HA) by soaking in simulated body fluid. The HA-coated SiV-PLA(K) fabric showed the release of silicate ions; the amount was reduced by 1/5 to 1/8 compared with that of the HA-coated SiV-PLA(M) fabric, and the excessive release was controlled. The preparation route of kneading at 200°C led to formation of a fabric with degradation behavior and ion releasability effective for bone regeneration.
两种无纺纤维材料，分别由硅掺杂文石相（SiV）和聚乳酸（PLA）组成，用于引导骨再生（GBR），通过静电纺丝法制备。其中一种纤维材料 SiV-PLA(M)，由 PLA 与分散在氯仿中的 SiV 溶液混合制成。另一种纤维材料 SiV-PLA(K)，由在 200°C 加热下捏合 SiV 和 PLA 制备的复合材料制成。SiV-PLA(K)纤维材料在稀 NaOH 溶液中具有更高的降解性。为了提高纤维材料的细胞相容性，将纤维浸泡在模拟体液中以涂覆羟基磷灰石（HA）。HA 涂覆的 SiV-PLA(K)纤维材料显示出硅酸盐离子的释放；与 HA 涂覆的 SiV-PLA(M)纤维材料相比，释放量减少了 1/5 至 1/8，并且控制了过量释放。在 200°C 下捏合的制备路线导致形成具有有效用于骨再生的降解行为和离子释放能力的纤维材料。
