Kasuga Toshihiro, Maeda Hirotaka, Kato Katsuhito, Nogami Masayuki, Hata Ken-ichiro, Ueda Minoru
Department of Materials Science and Engineering, Nagoya Institute of Technology, Gokiso-cho, Showa-ku, Japan.
Biomaterials. 2003 Aug;24(19):3247-53. doi: 10.1016/s0142-9612(03)00190-x.
A new type of ceramic-polymer biomaterial having excellent apatite-forming ability in simulated body fluid was prepared by hot-pressing a mixture of poly(-L-lactic acid) (PLA) and calcium carbonate (vaterite). After PLA dissolved in methylene chloride was mixed with calcium carbonate consisting of vaterite, the mixture was dried completely and subsequently hot-pressed uniaxially under a pressure of 40 MPa at 180 degrees C. When 30 wt% vaterite was introduced, the modulus of elasticity was effectively improved by 3.5-6 GPa, which was about twice higher than the modulus of PLA. The composite showed no brittle fracture behavior and a comparably high bending strength of approximately 50 MPa. The composite containing 30 wt% vaterite formed a 5-15-microm-thick bonelike apatite layer on its surface after soaking in SBF at 37 degrees C even for 1-3d.
通过对聚（-L-乳酸）（PLA）和碳酸钙（球霰石）的混合物进行热压，制备了一种在模拟体液中具有优异磷灰石形成能力的新型陶瓷-聚合物生物材料。将溶解在二氯甲烷中的PLA与由球霰石组成的碳酸钙混合后，将混合物完全干燥，随后在180℃、40MPa的压力下进行单轴热压。当引入30wt%的球霰石时，弹性模量有效提高了3.5-6GPa，约为PLA模量的两倍。该复合材料没有脆性断裂行为，弯曲强度相对较高，约为50MPa。含有30wt%球霰石的复合材料在37℃的SBF中浸泡1-3天后，其表面形成了一层5-15微米厚的骨状磷灰石层。
