Fujikura Kie, Obata Akiko, Lin Sen, Jones Julian R, Law Robert V, Kasuga Toshihiro
a Department of Frontier Materials , Graduate School of Engineering, Nagoya Institute of Technology , Gokiso-cho , Showa-ku , Nagoya , 466-8555 , Japan.
J Biomater Sci Polym Ed. 2012;23(10):1369-80. doi: 10.1163/092050611X582867. Epub 2012 May 8.
Siloxane/poly(L-lactic acid)/vaterite hybrid (SiPVH) fibremats constantly release calcium ions and ionic silicon species that have the potential to promote bone regeneration. In order to improve the mechanical properties of the SiPVH fibremats, the effect of various silixane-containing vaterite (denoted by SiV) content (10-60 wt%) on tensile properties was assessed. SiPVH fibremats with 30 wt% SiV content showed the highest tensile strength of 2.87 ± 0.39 MPa. Based on the energy-dissipation mechanism, failure initiated at the stress concentration points such as pores on the fibre surfaces or filler particles. In the case of the SiPVH fibremats with 20 and 30 wt% SiV, stress concentration occurred around the filler particles, where the applied energy was directly converted to small volume dilatation around the filler particles during failure of the fibres. This mechanism can be applied only when the material contains the polymer and the filler particles in specific ratios; 20 and 30 wt% filler content in the fibremat in this work. To coat the fibre surfaces with bone-like apatite SiPVH fibremats were soaked in modified simulated body fluid (1.5 SBF). Bone-like apatite formed on the surfaces of SiPVH fibremats with more than 30 wt% of SiV content in 1 day of soaking. These results reveal that the SiPVH fibremats containing 30 wt% SiV have suitable mechanical properties for bone filler materials.
硅氧烷/聚（L-乳酸）/球霰石杂化材料（SiPVH）纤维垫持续释放钙离子和离子硅物种，这些物质具有促进骨再生的潜力。为了提高SiPVH纤维垫的力学性能，评估了不同含硅球霰石（记为SiV）含量（10 - 60 wt%）对拉伸性能的影响。SiV含量为30 wt%的SiPVH纤维垫表现出最高的拉伸强度，为2.87 ± 0.39 MPa。基于能量耗散机制，失效始于应力集中点，如纤维表面的孔隙或填料颗粒。对于SiV含量为20 wt%和30 wt%的SiPVH纤维垫，应力集中发生在填料颗粒周围，在纤维失效过程中，施加的能量直接转化为填料颗粒周围的小体积膨胀。只有当材料中聚合物和填料颗粒以特定比例存在时，这种机制才适用；在本工作中纤维垫的填料含量为20 wt%和30 wt%。为了用类骨磷灰石包覆纤维表面，将SiPVH纤维垫浸泡在改性模拟体液（1.5 SBF）中。浸泡1天后，在SiV含量超过30 wt%的SiPVH纤维垫表面形成了类骨磷灰石。这些结果表明，含30 wt% SiV的SiPVH纤维垫具有适合作为骨填充材料的力学性能。
