自分泌运动因子：其在黑色素瘤细胞生物学中的作用及作为药理学靶点的研究

Autotaxin: its role in biology of melanoma cells and as a pharmacological target.

作者信息

Jankowski Maciej

机构信息

Department of Therapy Monitoring and Pharmacogenetics, Medical University of Gdańsk, Debinki 7, 80-211 Gdańsk, Poland.

出版信息

Enzyme Res. 2011 Mar 8;2011:194857. doi: 10.4061/2011/194857.

DOI:10.4061/2011/194857

PMID:21423677

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3057024/

Abstract

Autotaxin (ATX) is an extracellular lysophospholipase D (lysoPLD) released from normal cells and cancer cells. Activity of ATX is detected in various biological fluids. The lysophosphatidic acid (LPA) is the main product of ATX. LPA acting through specific G protein-coupled receptors (LPA(1)-LPA(6)) affects immunological response, normal development, and malignant tumors' formation and progression. In this review, the impact of autotoxin on biology of melanoma cells and potential treatment is discussed.

摘要

自分泌运动因子（ATX）是一种从正常细胞和癌细胞中释放出来的细胞外溶血磷脂酶D（lysoPLD）。在各种生物体液中都能检测到ATX的活性。溶血磷脂酸（LPA）是ATX的主要产物。LPA通过特定的G蛋白偶联受体（LPA(1)-LPA(6)）发挥作用，影响免疫反应、正常发育以及恶性肿瘤的形成和进展。在这篇综述中，讨论了自分泌运动因子对黑色素瘤细胞生物学特性的影响及潜在治疗方法。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/19ba/3057024/c88f1b57967a/ER2011-194857.001.jpg

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自分泌运动因子：其在黑色素瘤细胞生物学中的作用及作为药理学靶点的研究

Autotaxin: its role in biology of melanoma cells and as a pharmacological target.

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自分泌运动因子：其在黑色素瘤细胞生物学中的作用及作为药理学靶点的研究

Autotaxin: its role in biology of melanoma cells and as a pharmacological target.

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