去肾绵羊中促肾上腺皮质激素的血压及代谢效应

Blood pressure and metabolic effects of ACTH in anephric sheep.

Fan J S, Coghlan J P, Denton D A, Scoggins B A, Whitworth J A

Clin Exp Pharmacol Physiol. 1978 Nov-Dec;5(6):673-7. doi: 10.1111/j.1440-1681.1978.tb00724.x.

Abstract

ACTH (80--100 iu/day) was administered to seven sheep for 3--5 days following bilateral nephrectomy. 2. ACTH treatment produced rises in mean arterial pressure in anephric sheep similar to those observed in intact animals. Following withdrawal of ACTH, blood pressure declined over the following 72 h. 3. ACTH produced a transient fall in plasma potassium and anephric sheep, suggesting an internal redistribution mechanism for this ion. 4. These studies demonstrate that adrenal steroid hormones can modify blood pressure in the absence of the kidney.

摘要

双侧肾切除术后，给7只绵羊注射促肾上腺皮质激素（80 - 100国际单位/天），持续3 - 5天。2. 促肾上腺皮质激素治疗使无肾绵羊的平均动脉压升高，与在完整动物中观察到的情况相似。停用促肾上腺皮质激素后，血压在接下来的72小时内下降。3. 促肾上腺皮质激素使无肾绵羊的血浆钾短暂下降，提示该离子存在一种内部再分布机制。4. 这些研究表明，在没有肾脏的情况下，肾上腺类固醇激素可调节血压。