Rector W G, Adair O, Hossack K F, Rainguet S
Division of Gastroenterology, Denver General Hospital, University of Colorado Health Sciences Center.
Gastroenterology. 1990 Sep;99(3):766-70. doi: 10.1016/0016-5085(90)90966-5.
Increased blood volume, atrial size, and plasma concentration of atrial natriuretic factor are described in cirrhosis. Their interrelationships were examined in 17 men with alcoholic liver disease, 7 with and 10 without ascites. Atrial size was determined by two-dimensional echocardiography. Patients with cirrhosis had significantly increased left atrial volume and plasma concentration of atrial natriuretic factor when compared with normal male subjects. Right atrial volume was normal in patients with cirrhosis, as was left ventricular function. Patients with ascites had significantly increased blood volume and plasma atrial natriuretic factor concentration compared with patients without ascites. Left and right atrial volume did not differ between the groups. Blood volume correlated significantly with left atrial volume, which correlated significantly with plasma concentration of atrial natriuretic factor. Cirrhosis is associated with related increases in vascular volume, left atrial size, and plasma atrial natriuretic factor concentration. Increased blood volume probably contributes to the increase in left atrial volume, which is in turn one reason for the elevation of plasma atrial natriuretic factor concentration.
肝硬化患者存在血容量增加、心房增大及心房利钠因子血浆浓度升高的情况。对17例酒精性肝病男性患者进行了研究，其中7例有腹水，10例无腹水，以探讨它们之间的相互关系。通过二维超声心动图测定心房大小。与正常男性受试者相比，肝硬化患者的左心房容积和心房利钠因子血浆浓度显著增加。肝硬化患者的右心房容积正常，左心室功能也正常。与无腹水患者相比，有腹水患者的血容量和血浆心房利钠因子浓度显著增加。两组之间左、右心房容积无差异。血容量与左心房容积显著相关，左心房容积又与心房利钠因子血浆浓度显著相关。肝硬化与血管容量、左心房大小及血浆心房利钠因子浓度的相关增加有关。血容量增加可能导致左心房容积增加，而这反过来又是血浆心房利钠因子浓度升高的一个原因。
