Orthopaedic Research Laboratory, Department of Orthopaedic Surgery and Traumatology, Odense University Hospital, Institute of Clinical Research, University of Southern Denmark, Sdr. Boulevard 29, 5000, Odense C, Denmark.
J Mater Sci Mater Med. 2011 May;22(5):1111-8. doi: 10.1007/s10856-011-4290-y. Epub 2011 Mar 24.
Eight groups of calcium-phosphate scaffolds for bone implantation were prepared of which seven were reinforced with biopolymers, poly lactic acid (PLA) or hyaluronic acid in different concentrations in order to increase the mechanical strength, without significantly impairing the microarchitecture. Controls were un-reinforced calcium-phosphate scaffolds. Microarchitectural properties were quantified using micro-CT scanning. Mechanical properties were evaluated by destructive compression testing. Results showed that adding 10 or 15% PLA to the scaffold significantly increased the mechanical strength. The increase in mechanical strength was seen as a result of increased scaffold thickness and changes to plate-like structure. However, the porosity was significantly lowered as a consequence of adding 15% PLA, whereas adding 10% PLA had no significant effect on porosity. Hyaluronic acid had no significant effect on mechanical strength. The novel composite scaffold is comparable to that of human bone which may be suitable for transplantation in specific weight-bearing situations, such as long bone repair.
制备了 8 组用于骨植入的钙磷支架，其中 7 组用不同浓度的生物聚合物聚乳酸（PLA）或透明质酸增强，以提高机械强度，而不会显著损害微观结构。对照组为未增强的钙磷支架。使用微 CT 扫描定量微结构特性。通过破坏性压缩试验评估机械性能。结果表明，向支架中添加 10%或 15%的 PLA 可显著提高机械强度。机械强度的增加是由于支架厚度的增加和板状结构的变化所致。然而，添加 15%的 PLA 会显著降低孔隙率，而添加 10%的 PLA 对孔隙率没有显著影响。透明质酸对机械强度没有显著影响。新型复合支架与人骨相当，可能适用于特定承重情况下的移植，如长骨修复。
