Department of Social and Environmental Mediciae, Osaka University Gradaate School of Medicine, 2-2 Yamada-Oka, 565-0871, Suita, Osaka, Japan.
Environ Health Prev Med. 2002 Apr;7(1):11-4. doi: 10.1007/BF02898060.
The purpose of this study was to investigate the relation between lifestyle and the antimutagenicity of saliva.
Subjects were 52 healthy female university students. The collection of the saliva samples and the lifestyle measurements were carried out for them. The anti-mutagenicity of the saliva was measured using the umu test.
With regard to the lifestyle items, only "nutrient balance" tended to contribute positively to the inhibiting capacity of the saliva on the mutagenicity of AF-2. In addition, there was a significant inverse correlation between the score of 7 other items and the inhibiting capacity of the saliva (r=-0.32; p<0.05). We also found a significant relation between their tea and/or coffee consumption and the inhibiting capacity of the saliva.
These findings suggest that the inhibiting capacity of saliva worked to decrease mutagen levels that were enhanced by poor lifestyle. In addition, "nutrient balance" may contribute to the inhibiting capacity of the saliva independent of 7 other items. With regard to the tea and/or coffee consumption. further studies should be carried out.
本研究旨在探讨生活方式与唾液抗诱变活性之间的关系。
研究对象为 52 名健康的女性大学生。为她们采集唾液样本并进行生活方式测量。采用 umu 试验测定唾液的抗诱变活性。
就生活方式项目而言，只有“营养平衡”一项对唾液抑制 AF-2 致突变性的能力有正向作用。此外，其他 7 项的评分与唾液的抑制能力呈显著负相关（r=-0.32；p<0.05）。我们还发现他们的茶和/或咖啡的摄入量与唾液的抑制能力之间存在显著关系。
这些发现表明，唾液的抑制能力可以降低不良生活方式增强的诱变物水平。此外，“营养平衡”可能独立于其他 7 项对唾液的抑制能力有贡献。至于茶和/或咖啡的摄入，还需要进一步的研究。
