尼泊尔南部农村特赖地区居民血清中生育酚和视黄醇与脂质标准化的营养状况。

Serum nutritional status of tocopherol and retinol normalized to lipids of persons living in the southern rural Terai region in Nepal.

机构信息

Department of Health and Nutrition, Graduate School of Human Life Science, Osaka City University, 3-3-138 Sugimoto, Sumiyoshi-ku, 558-8585, Osaka, Japan.

出版信息

Environ Health Prev Med. 2004 Jan;9(1):13-21. doi: 10.1265/ehpm.9.13.

DOI:10.1265/ehpm.9.13

PMID:21432333

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2723383/

Abstract

OBJECTIVE

The present study examined the levels of serum α-Tocopherol (Toc), retinol (Ret), cholesterol (Chol) and triglycerides (TG), and their correlations in the sera of people in Nepal.

METHODS

The survey was conducted on the general populace in the agricultural Terai region in southern Nepal. The study population consisted of 93 males and 83 females aged 10-68 years. Serum Toc and Ret were measured by high-performance liquid chromatography.

RESULTS

No significant differences were observed between the genders for the average of total Chol (T-Chol) (140 and 145 mg/100 ml, respectively), HDL-C (45 and 47 mg/100 ml), LDL-C (94 and 97 mg/100 ml), and TG (106 and 110 mg/100 ml), and the ratio of LDL/HDL (2.16). The levels of mean Toc (4.32 and 4.27 μg/ml) were about the same for both genders, while the mean Ret levels were significantly higher for males (624 ng/ml) than for females (535 ng/ml) (p<0.001). A direct relationship was found between the levels of Toc and Ret (r=0.46, p<0.001 and r=0.28, p<0.05 for males and females, respectively). Serum levels of Toc and Ret were positively related to the levels of Chol (r=0.48 and r=0.58, p<0.001 for males and r=0.49, p<0.01 and r-0.28, p<0.05 for females, respectively). The ratio of Toc/TG normalized to serum TG was directly correlated to the ratio of Ret/TG (r=0.79 for males, and r=0.72 for females, p<0.001, respectively) and the ratios of Toc/TG and Ret/TG were negatively related to the LDL/HDL levels (r=-0.49 and r=-0.43, for males, and r=-0.46 and r=-0.57 for females, p<0.001, respectively).

CONCLUSION

The levels of Toc and Ret were low in the sera of people living in the southern rural Terai region in Nepal, and it was found that lower levels of Toc and Ret normalized to TG increased the ratio of LDL/HDL. These results suggest that greater intake of foods rich in Toc and Ret should be encouraged to reduce the erisk of coronary heart disease.

摘要

目的

本研究检测了尼泊尔农村泰莱地区人群血清中 α-生育酚（Toc）、视黄醇（Ret）、胆固醇（Chol）和甘油三酯（TG）的水平，并对其相关性进行了分析。

方法

本研究在尼泊尔南部农业泰莱地区的普通人群中进行。研究人群包括 93 名男性和 83 名女性，年龄在 10-68 岁之间。血清 Toc 和 Ret 采用高效液相色谱法测定。

结果

男女两性的总胆固醇（T-Chol）平均值（分别为 140 和 145mg/100ml）、高密度脂蛋白胆固醇（HDL-C）（分别为 45 和 47mg/100ml）、低密度脂蛋白胆固醇（LDL-C）（分别为 94 和 97mg/100ml）和甘油三酯（TG）（分别为 106 和 110mg/100ml）以及 LDL/HDL 比值（2.16）均无显著性别差异。男女两性的平均 Toc 水平（4.32 和 4.27μg/ml）相近，而男性的平均 Ret 水平显著高于女性（624ng/ml 比 535ng/ml）（p<0.001）。Toc 和 Ret 水平之间存在直接关系（r=0.46，p<0.001 和 r=0.28，p<0.05，分别为男性和女性）。血清 Toc 和 Ret 水平与 Chol 水平呈正相关（r=0.48 和 r=0.58，p<0.001，分别为男性和 r=0.49，p<0.01 和 r-0.28，p<0.05，分别为女性）。Toc/TG 与血清 TG 之比与 Ret/TG 之比呈正相关（r=0.79，男性；r=0.72，女性；p<0.001），并且 Toc/TG 和 Ret/TG 比值与 LDL/HDL 水平呈负相关（r=-0.49，男性；r=-0.43，女性；p<0.001）。