大鼠肺内纤维原性粉尘致纤维化的实验研究。
Experimental study on fibrogenic effect of fur dust on rat lung.
机构信息
Division of Pneumoconiosis, School of Public Health, China Medical University, China.
出版信息
Environ Health Prev Med. 2003 Jan;7(6):292-4. doi: 10.1007/BF02908889.
OBJECTIVE
The fibrogenicity of fur dust was studied in rat lung tissues.
METHODS
Intratracheal instillation of fur dust, morphologic examination of lungs and analysis of collagen content were performed in Wistar rats.
RESULTS
Morphologic examination revealed that the earliest changes consisted of alveolar edema, increased numbers of intraalveolar macrophages, and marked thickening of interalveolar septa with mixed cellular infiltrate. After sixth months, there was moderate thickening of the alveolar walls and the peribronchioli. After 12 months, interstitial positive fibrosis of the alveolar wall and the peribronchioli were weakly seen. In the carding dust group (silica content 17.6%), interstitial nodules were observed composed of fibroblasts, reticular fibers, and collagen fibers. Electron microscopic examination also showed that alveolar walls became thickened and collagen fiber bundles were seen around bronchioles and small vessels in the carding groups after 12 months. At all stages of analysis, the collagen content in lungs of the fur dust groups was significantly higher than that of the control group.
CONCLUSIONS
Our study suggested that fur dust might induce weak interstitial fibrosis in the lung.
目的
研究皮屑粉尘的致纤维化作用。
方法
对 Wistar 大鼠进行皮屑粉尘气管内注入，观察肺部形态学改变，并分析胶原含量。
结果
形态学检查显示，最早的改变包括肺泡水肿、肺泡内巨噬细胞增多、肺泡间隔明显增厚并伴有混合细胞浸润。6 个月后，肺泡壁和细支气管周围中度增厚。12 个月后，可见肺泡壁和细支气管周围间质阳性纤维化。梳理粉尘组（二氧化硅含量 17.6%）中可见由成纤维细胞、网状纤维和胶原纤维组成的间质小结节。电镜检查也显示，12 个月后梳理组的肺泡壁变厚，细支气管和小血管周围可见胶原纤维束。在所有分析阶段，皮屑粉尘组肺组织中的胶原含量明显高于对照组。
结论
本研究表明皮屑粉尘可能导致肺部弱的间质纤维化。
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