Department of Public Health, Hyogo College of Medicine, 1-1, Mukogawa-cho, Nishinomiya-City, 663, Hyogo, Japan.
Environ Health Prev Med. 1997 Jan;1(4):178-83. doi: 10.1007/BF02931213.
To investigate the changes in the concentration of essential metals in organs caused by exposure to cadmium (Cd) and by aging, Cd was administered subcutaneously in single doses of 0.3, 0.9 and 2.7 nig/kg to female rats 10 and 40 weeks of age. The animals were sacrificed on the 7th day after the administration. The concentration of Cd, zinc (Zn), copper (Cu), iron (Fe) and manganese (Mn) in the liver and the kidney was determined and the relations between the concentration of Cd and that of other metals were investigated.1) In 10-week-old rats, the amount of Cd accumulated in the liver and the kidney increased linearly with increasing doses of Cd, while in 40-week-old rats, suppressed accumulation of Cd in the liver and increased accumulation of Cd in the kidney were found after administration of the high dose.2) The concentration of Zn in the liver and the kidney both increased with increasing doses of Cd. There was no age-related difference.3) The concentration of Cu in the liver increased in the animals which received the intermediate and the high dose, irrespective of age. The concentration of Cu in the kidney showed no changes caused by Cd administration or by aging.4) The concentration of Fe in the liver increased in both 10-week-old and 40-week-old rats which received the high dose. The concentration was higher in 40-week-old rats than in 10-week-old rats. The Fe concentration in the kidney and the Mn concentration in the liver and the kidney was not affected by Cd administration or by aging.5) Discriminant analysis, by age, suggested that the amount of metals in the liver and the kidney was more likely to be affected by exposure to Cd in young individuals and less likely to be affected by exposure to Cd with the increase of age.
为了研究镉（Cd）暴露和衰老引起的器官中必需金属浓度的变化，将 Cd 以 0.3、0.9 和 2.7 μg/kg 的剂量分别皮下注射给 10 周和 40 周龄的雌性大鼠。动物在给药后第 7 天被处死。测定肝、肾中 Cd、锌（Zn）、铜（Cu）、铁（Fe）和锰（Mn）的浓度，并研究 Cd 与其他金属浓度之间的关系。1）在 10 周龄大鼠中，肝和肾中 Cd 的积累量随 Cd 剂量的增加而线性增加，而在 40 周龄大鼠中，高剂量给药后肝中 Cd 的积累受到抑制，而肾中 Cd 的积累增加。2）肝、肾中 Zn 的浓度随 Cd 剂量的增加而增加，与年龄无关。3）肝 Cu 浓度在接受中、高剂量的动物中均增加，与年龄无关。肾 Cu 浓度因 Cd 给药或衰老而无变化。4）肝 Fe 浓度在接受高剂量的 10 周龄和 40 周龄大鼠中均增加，40 周龄大鼠的浓度高于 10 周龄大鼠。肾 Fe 浓度和肝、肾 Mn 浓度不受 Cd 给药或衰老的影响。5）按年龄进行判别分析表明，肝、肾中金属的含量更容易受到年轻个体接触 Cd 的影响，而随着年龄的增长，接触 Cd 的影响则较小。
