Tiran B, Karpf E, Tiran A
Institute of Medical Biochemistry, Karl Franzens University Graz.
Arch Environ Health. 1995 May-Jun;50(3):242-6. doi: 10.1080/00039896.1995.9940394.
Selenium and cadmium concentrations were investigated in 60 autopsy tissue samples obtained from fetal life up to adulthood (defined in this study as 25-87 y of age) in Styria, a moderately industrialized region in Austria that has a low selenium supply. During the first 2 y after birth, median liver selenium concentrations were slightly lower (i.e., 1.5 nmol/g wet weight) than concentrations found in fetal life (i.e., 2.9 nmol/g) and adulthood (2.1 nmol/g). Whereas in the fetal period median selenium content in the kidney cortex (2.1 nmol/g) and the thyroid gland (1.6 nmol/g) was lower than that found in the liver, the reverse was true for adults (i.e., kidney, 5.5 nmol/g; thyroid, 4.3 nmol/g). Tissue cadmium concentrations approached 0 during gestation. Accumulation in the kidney and liver commenced immediately after birth. In the thyroid gland of adults, significantly higher concentrations of cadmium were found. Median concentrations in adults showed no statistical significant age dependency (i.e., liver, 7.6 nmol/g; kidney, 59.8 nmol/g; thyroid, 11.2 nmol/g). In summary, the data revealed very low tissue selenium concentrations and low cadmium burdens for the Styrian population that was not exposed occupationally.
在奥地利施蒂利亚州（一个工业化程度中等且硒供应较低的地区），对60份从胎儿期到成年期（本研究定义为25 - 87岁）的尸检组织样本中的硒和镉浓度进行了调查。在出生后的头两年，肝脏硒浓度中位数（即1.5纳摩尔/克湿重）略低于胎儿期（即2.9纳摩尔/克）和成年期（2.1纳摩尔/克）。在胎儿期，肾皮质（2.1纳摩尔/克）和甲状腺（1.6纳摩尔/克）中的硒含量中位数低于肝脏，而成年人则相反（即肾脏，5.5纳摩尔/克；甲状腺，4.3纳摩尔/克）。孕期组织镉浓度接近0。出生后肾脏和肝脏立即开始镉的蓄积。在成年人的甲状腺中，发现镉浓度显著更高。成年人的浓度中位数没有显示出统计学上显著的年龄依赖性（即肝脏，7.6纳摩尔/克；肾脏，59.8纳摩尔/克；甲状腺，11.2纳摩尔/克）。总之，数据显示施蒂利亚州未从事职业暴露人群的组织硒浓度非常低，镉负荷也很低。
