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Silibinin mode of action against hepatitis C virus: a controversy yet to be resolved.

作者信息

Dahari Harel, Guedj Jeremie, Perelson Alan S

出版信息

Hepatology. 2011 Aug;54(2):749. doi: 10.1002/hep.24310. Epub 2011 Jun 27.

Abstract
摘要

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A perspective on modelling hepatitis C virus infection.
J Viral Hepat. 2010 Dec;17(12):825-33. doi: 10.1111/j.1365-2893.2010.01348.x. Epub 2010 Aug 15.
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Successful HCV eradication and inhibition of HIV replication by intravenous silibinin in an HIV-HCV coinfected patient.
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Silibinin is a potent antiviral agent in patients with chronic hepatitis C not responding to pegylated interferon/ribavirin therapy.
Gastroenterology. 2008 Nov;135(5):1561-7. doi: 10.1053/j.gastro.2008.07.072. Epub 2008 Aug 3.
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Hepatitis C viral dynamics in vivo and the antiviral efficacy of interferon-alpha therapy.
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