Xiao Er, Xiong Hui, Zhao Ying-Hong, Deng Xu-Kun, Mei Zhi-Nan
College of Pharmacy, South-central University for Nationalities, Wuhan 430074, China.
Zhong Yao Cai. 2010 Nov;33(11):1704-7.
To study the acute toxicity of the crude and processed products of Entada phaseoloides and their effects on gastrointestinal movement in mice.
Using the method of intragastric administration, to observe the acute toxicity of the crude and processed products of Entada phaseoloides in mice and determine their LD50. With the methods of charcoal propulsion of small intestine and methyl orange colorimetry of gastric emptying, to study the impact of the crude and processed products of Entada on gastrointestinal movement in mice.
The oral LD50 of crude Entada phaseoloides, No. 1 and No. 2 processed products of Entada phaseoloides in mice were 27.17, 35.13, 42.18 g/kg body weight. Crude and processed products of Entada phaseoloides can significantly promote the enteric propulsion of normal mice, and can significantly counteract the depressing status induced by atropine, but have no influence on the overactive status induced by neostigmine. The high, middle and low-dose of groups showed significant inhibition of the gastric emptying in normal mice.
Processed Entada phaseoloides showed effects on the enteric propulsion of normal and depressing mice, can restrain the gastric emptying under normal mice, but its safety is better than crude Entada phaseoloides.
研究过江龙生品与炮制品的急性毒性及其对小鼠胃肠运动的影响。
采用灌胃给药法，观察过江龙生品与炮制品对小鼠的急性毒性并测定其半数致死量（LD50）。采用小肠炭末推进法和胃排空甲基橙比色法，研究过江龙生品与炮制品对小鼠胃肠运动的影响。
过江龙生品、炮制品1、炮制品2小鼠灌胃的LD50分别为27.17、35.13、42.18 g/kg体重。过江龙生品与炮制品均能显著促进正常小鼠小肠推进运动，能显著对抗阿托品所致的抑制状态，但对新斯的明所致的亢进状态无影响。高、中、低剂量组对正常小鼠胃排空均有显著抑制作用。
炮制后的过江龙对正常及抑制状态小鼠小肠推进运动均有影响，对正常小鼠胃排空有抑制作用，但其安全性优于过江龙生品。
