Zhang Xiu-ming, Luo Jia-bo
Traditional Chinese Medicinal School, Southern Medical University, Guangzhou 510515, China.
Zhong Yao Cai. 2010 Feb;33(2):236-9.
To discuss the significance of processing and complex prescription with Herba Ephedrae, the effects of Herba Ephedrae, Honey-fried Herba Ephedrae and Maxingshigan decoction on autonomic activities in mice were compared.
110 female Kunming mice were divided into 11 groups, namely normal saline group (NS), ephedrine group (E), high dose Herba Ephedrae group (MH-H), moderate dose Herba Ephedrae group (MH-M), low dose Herba Ephedrae group (MH-L) ,high dose Honey-fried Herba Ephedrae group (ZMH-H), moderate dose Honey-fried Herba Ephedrae group (ZMH-M),low dose Honey-fried Herba Ephedrae group (ZMH-L), high dose Maxingshigan decoction group (MX-H), moderate dose Maxingshigan decoction group (MX-M) and low dose Maxingshigan decoction group (MX-L). The numbers of autonomic activity in 15 minutes before intragastric administration (ig), and after ig 0.5, 1, 2, 3, 4 h were determined.
There was interaction between time and groups. There were very significant differences between before ig and all time-points after ig (P < 0.01). 30 minutes after ig,there were significant differences between E and NS,E and ZMH-L,E and MX-L (P < 0.05). 1 h after ig, there were significant differences between MX-M and NS (P < 0.05). 3 h after ig, there were significant differences between MX-M and MH-L (P < 0.05). 30 minutes after ig, both ZMH-L and MX-L could reduce the number of autonomic activity in some extent compare with MH-L. 1 h or 2 h after ig, ZMH-L could reduce the number of autonomic activity in some extent compare with MH-L 4 h after ig, MX-L could reduce the number of autonomic activity in some extent compare with MH-L.
Under the condition of this study, regarding autonomic activity as index, both ZMH-L and MX-L can reduce center stimulation in some extent.
探讨麻黄炮制及复方配伍的意义，比较麻黄、蜜麻黄及麻杏石甘汤对小鼠自主活动的影响。
将110只雌性昆明小鼠分为11组，即生理盐水组（NS）、麻黄碱组（E）、麻黄高剂量组（MH-H）、麻黄中剂量组（MH-M）、麻黄低剂量组（MH-L）、蜜麻黄高剂量组（ZMH-H）、蜜麻黄中剂量组（ZMH-M）、蜜麻黄低剂量组（ZMH-L）、麻杏石甘汤高剂量组（MX-H）、麻杏石甘汤中剂量组（MX-M）和麻杏石甘汤低剂量组（MX-L）。测定灌胃前（ig）及灌胃后0.5、1、2、3、4 h 15分钟内的自主活动次数。
时间与组间存在交互作用。灌胃前与灌胃后各时间点比较，差异有极显著性（P<0.01）。灌胃后30分钟，E与NS、E与ZMH-L、E与MX-L比较，差异有显著性（P<0.05）。灌胃后1小时，MX-M与NS比较，差异有显著性（P<0.05）。灌胃后3小时，MX-M与MH-L比较，差异有显著性（P<0.05）。灌胃后30分钟，ZMH-L和MX-L与MH-L比较，均可在一定程度上减少自主活动次数。灌胃后1小时或2小时，ZMH-L与MH-L比较，可在一定程度上减少自主活动次数；灌胃后4小时，MX-L与MH-L比较，可在一定程度上减少自主活动次数。
在本研究条件下，以自主活动为指标，ZMH-L和MX-L均可在一定程度上减轻中枢兴奋。
