Yang Wei-feng, Wang Jian, Liu Li-na, Xiao Wu
Pharmacy College, Hubei University of Traditional Chinese Medicine, Wuhan 430065, China.
Zhong Yao Cai. 2011 Jan;34(1):33-6.
To observe the changes of interstitial cells of Cajal (ICC) in stomach and small intestine of rats with honey-stir-baked Radix Polygalae, crude Radix Polygalae and its saponins, so as to study mechanism of crude Radix Polygalae reducing the motility disorder in gastrointestinal tract.
Immunohistochemical staining was used to investigate the distribution of c-kit positive ICC in stomach and small intestine.
Compared with control group, the c-kit positive ICC in stomach and small intestine of crude Radix Polygalae and its saponins groups were both markedly decreased in model group (both P < 0.01), while honey-stir-baked Radix Polygalae group can not (P > 0.05).
The motility disorder in gastrointestinal tract caused by crude Radix Polygalae and its saponins may be associated with the changes of ICC number in stomach and small intestine. Honey-stir-baked Radix Polygalae can protect ICC in some extent.
观察蜜炙远志、生远志及其皂苷对大鼠胃和小肠中Cajal间质细胞（ICC）的影响，以探讨生远志减轻胃肠道动力障碍的机制。
采用免疫组织化学染色法观察胃和小肠中c-kit阳性ICC的分布。
与对照组比较，模型组生远志及其皂苷组胃和小肠中c-kit阳性ICC均明显减少（均P<0.01），而蜜炙远志组无明显变化（P>0.05）。
生远志及其皂苷所致胃肠道动力障碍可能与胃和小肠中ICC数量变化有关，蜜炙远志对ICC有一定的保护作用。
