Tan Yia Swam, Ng Lay Guat, Yip Sidney Kam-Hung, Tay Miah-Hiang, Lim Alvin Soon-Tiong, Tien Sim Leng, Cheng Liang, Tan Puay Hoon
Department of Urology, Singapore General Hospital, Singapore.
Anal Quant Cytol Histol. 2010 Aug;32(4):239-45.
Synovial sarcoma of the kidney is rare. It is clinicoradiologically indistinguishable from the more frequently encountered renal cell carcinoma. Histologically it needs to be differentiated from other spindle cell lesions occurring within the kidney, including a spectrum of benign to malignant tumors. Among malignant spindle cell tumors of the kidney, mimics of synovial sarcoma are sarcomatoid renal cell carcinoma, sarcomatoid urothelial carcinoma and other primary sarcomas, such as leiomyosarcoma and malignant fibrous histiocytoma.
Four cases of synovial sarcoma originated in the kidney, with this report focusing on clinicopathologic and differential diagnostic features.
The correct diagnosis of synovial sarcoma requires support by an immunohistochemical panel as well as adjunctive investigations like polymerase chain reaction and fluorescence in situ hybridization to determine the presence of the SYT-SSX fusion gene and translocation (X,18), respectively.
肾脏滑膜肉瘤罕见。其临床放射学表现与更常见的肾细胞癌难以区分。在组织学上，它需要与发生于肾脏内的其他梭形细胞病变相鉴别，包括一系列从良性到恶性的肿瘤。在肾脏恶性梭形细胞肿瘤中，滑膜肉瘤的模仿者有肉瘤样肾细胞癌、肉瘤样尿路上皮癌以及其他原发性肉瘤，如平滑肌肉瘤和恶性纤维组织细胞瘤。
4例起源于肾脏的滑膜肉瘤，本报告重点关注其临床病理及鉴别诊断特征。
滑膜肉瘤的正确诊断需要免疫组织化学检测组合以及如聚合酶链反应和荧光原位杂交等辅助检查的支持，以分别确定SYT-SSX融合基因的存在和（X；18）易位。
