Huang Linzhang, Zhao Hongfang, Huang Baokang, Zheng Chengjian, Peng Wei, Qin Luping
Department of Pharmacognosy, School of Pharmacy, Second Military Medical University, Shanghai, PR China.
Pharmazie. 2011 Feb;66(2):83-97.
Acanthopanax senticosus (Rupr. et Maxim) Harms (Araliaceae), also called Siberian Ginseng, Eleutherococcus senticosus, and Ciwujia in Chinese, is a widely used traditional Chinese herb that could invigorate qi, strengthen the spleen, and nourish kidney in the theory of Traditional Chinese Medicine. With high medicinal value, Acanthopanax senticosus (AS, thereafter) is popularly used as an "adaptogen" like Panax ginseng. In recent decades, a great number of chemical, pharmacological, and clinical studies on AS have been carried out worldwide. Several kinds of chemical compounds have been reported, including triterpenoid saponins, lignans, coumarins, and flavones, among which, phenolic compounds such as syringin and eleutheroside E, were considered to be the most active components. Considerable pharmacological experiments both in vitro and in vivo have persuasively demonstrated that AS possessed anti-stress, antiulcer, anti-irradiation, anticancer, anti-inflammatory and hepatoprotective activities, etc. The present review is an up-to-date and comprehensive analysis of the botany, chemistry, pharmacology, toxicity and clinical trials of AS.
刺五加（Acanthopanax senticosus (Rupr. et Maxim) Harms，五加科），又称西伯利亚人参、刺蒺藜，中文名为刺五加，是一种广泛应用的传统中药，在中医理论中具有补气、健脾、补肾的功效。刺五加具有很高的药用价值，像人参一样被广泛用作“适应原”。近几十年来，全球范围内对刺五加进行了大量的化学、药理和临床研究。已报道了几种化合物，包括三萜皂苷、木脂素、香豆素和黄酮类化合物，其中，丁香苷和刺五加苷E等酚类化合物被认为是最具活性的成分。大量的体外和体内药理实验令人信服地证明，刺五加具有抗应激、抗溃疡、抗辐射、抗癌、抗炎和保肝等活性。本综述是对刺五加的植物学、化学、药理学、毒性和临床试验的最新综合分析。
