Department of Biomaterials and Biomimetics, New York University, New York, NY, USA.
Clin Oral Implants Res. 2012 Mar;23(3):373-8. doi: 10.1111/j.1600-0501.2010.02150.x. Epub 2011 Mar 24.
To investigate the effect of Si addition on a nanometer-scale roughness Ca and P implant surfaces in a canine tibia model by biomechanical and histomorphometric evaluations.
The implant surfaces comprised a resorbable media CaP microblasted (control) and a CaP resorbable media+silica-boost microblasted (experimental) surfaces. Surfaces were characterized by scanning electron microscopy (SEM), X-ray photoelectron spectroscopy (XPS), and optical interferometry (IFM) down to the nanometric level. The animal model involved the bilateral placement of control (n=24) and experimental surface (n=24) implants along the proximal tibiae of six dogs, remaining in vivo for 2 or 4 weeks. After euthanization, half of the specimens were torqued-to-interface failure, and the other half was subjected to histomorphologic and bone-to-implant contact (BIC) evaluation. Torque and BIC statistical evaluation was performed by the Friedman test at 95% level of significance, and comparisons between groups was performed by the Dunn test.
IFM and SEM observations depicted comparable roughness parameters for both implant surfaces on the micrometer and nanometer scales. XPS analysis revealed similar chemical composition, except for the addition of Si on the experimental group. Torque-to-interface failure and BIC mean values showed no significant differences (P=0.25 and 0.51, respectively) at both 2- and 4-week evaluation points for experimental and control groups. Early bone healing histomorphologic events were similar between groups.
The experimental surface resulted in not significantly different biomechanical fixation and BIC relative to control. Both surfaces were biocompatible and osseoconductive.
通过生物力学和组织形态计量学评估，研究 Si 添加剂对犬胫骨模型中纳米级粗糙度 Ca 和 P 植入表面的影响。
植入物表面由可吸收介质 CaP 微喷砂（对照）和 CaP 可吸收介质+硅增强微喷砂（实验）表面组成。通过扫描电子显微镜（SEM）、X 射线光电子能谱（XPS）和光学干涉仪（IFM）对表面进行纳米级特征分析。动物模型包括在 6 只狗的胫骨近端双侧放置对照（n=24）和实验表面（n=24）植入物，在体内保留 2 或 4 周。安乐死后，一半标本进行界面扭断试验，另一半进行组织形态学和骨-植入物接触（BIC）评估。在 95%置信水平下，通过 Friedman 检验对扭矩和 BIC 进行统计评估，并通过 Dunn 检验进行组间比较。
IFM 和 SEM 观察显示两种植入物表面在微米和纳米尺度上具有相似的粗糙度参数。XPS 分析显示除实验组添加 Si 外，两种植入物表面的化学组成相似。在 2 周和 4 周评估时，界面扭断试验和 BIC 平均值在实验组和对照组之间均无显著差异（P=0.25 和 0.51）。两组的早期骨愈合组织形态学事件相似。
与对照相比，实验组的生物力学固定和 BIC 无显著差异。两种表面均具有生物相容性和骨传导性。
