Xu Xiaojun, Fu Junfen, Fang Yanlan, Liang Li
Division of Hematology/Oncology, Children's Hospital of Zhejiang University School of Medicine, Hangzhou, PR China.
J Pediatr Hematol Oncol. 2011 May;33(4):306-11. doi: 10.1097/MPH.0b013e3181fce3b0.
Kimura disease is a chronic inflammatory disease,which frequently affects middle-aged Asian men, although children are seldom affected by it. Therefore, the characteristics of the Kimura disease of childhood have not been well illustrated. In this report, we have described a case of Kimura disease and have summarized 29 childhood cases reported in Chinese people from 1988 to 2009 by using 3 Chinese journal search engines. Most of these cases were from provinces near the eastern and southern coast of China. Boys were predominantly affected. Head and neck are the most frequently involved sites of subcutaneous masses (24 of the 29, 82.8%). On laboratory investigations, peripheral blood eosinophilia (25 of 26, 96.2%) and elevated immunoglobulin E level (13 of 13, 100%) were common. Kimura disease was associated with high incidence of nephritic syndrome (8 of the 29, 27.6%) and eczema rash (13 of 29, 44.8%). Surgery excision, steroids, and chemotherapy were the main therapy methods in this cohort. For patients with follow-up data, 12 experienced recurrence, with a recurrence rate of 60.0%. Pediatricians need to be aware of this disease when dealing with patients with lymphadenopathy. A standard and effective treatment protocol would improve the outcome of the Kimura disease.
木村病是一种慢性炎症性疾病，常累及中年亚洲男性，儿童很少受其影响。因此，儿童木村病的特征尚未得到充分阐明。在本报告中，我们描述了一例木村病病例，并使用3个中文期刊搜索引擎总结了1988年至2009年中国人报告的29例儿童病例。这些病例大多来自中国东部和南部沿海附近省份。男孩受影响为主。头颈部是皮下肿块最常累及的部位（29例中的24例，82.8%）。实验室检查显示，外周血嗜酸性粒细胞增多（26例中的25例，96.2%）和免疫球蛋白E水平升高（13例中的13例，100%）很常见。木村病与肾病综合征（29例中的8例，27.6%）和湿疹皮疹（29例中的13例，44.8%）的高发病率相关。手术切除、类固醇和化疗是该队列中的主要治疗方法。对于有随访数据的患者，12例复发，复发率为60.0%。儿科医生在处理淋巴结病患者时需要了解这种疾病。一个标准有效的治疗方案将改善木村病的治疗效果。
