Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
J Neurovirol. 2011 Apr;17(2):159-65. doi: 10.1007/s13365-011-0023-8. Epub 2011 Mar 25.
The objectives of this study are to compare the results of newer performance-based functional assessments in the study of HIV-associated neurocognitive disorders (HAND) and to correlate these functional assessments with specific levels of severity of HAND. One hundred fourteen HIV+ subjects in an existing cohort were evaluated with a medical history, neurological exam, neuropsychological test battery as well as subjective and novel objective measures of functional abilities. Self-reported measures of functional performance included the Karnofsky Performance Scale, a questionnaire for instrumental activities of daily living, and a questionnaire for physical quality of life measures. The newer objective functional performance assessments included the Columbia Medication Management and the San Diego Finances tests. These newer performance-based measures of function were assessed for their ability to predict level of HAND. The two objective measures of functional performance, The Columbia Medication Management Scale and the San Diego Finances Test, were both associated with levels of severity of HAND. The Karnofsky Performance Scale and the questionnaires for role and physical quality of life were subjective measures that were also associated with specific levels of HAND. Newer measures of functional performance can be used to objectively evaluate functional impairment in HAND and validate different levels of HAND.
本研究的目的是比较新型基于表现的功能评估在 HIV 相关认知障碍（HAND）研究中的结果，并将这些功能评估与 HAND 的特定严重程度相关联。现有的队列中，114 名 HIV 阳性患者接受了病史、神经系统检查、神经心理学测试组合以及主观和新颖的客观功能能力测量评估。功能表现的自我报告测量包括 Karnofsky 表现量表、日常生活活动工具问卷以及身体生活质量措施问卷。新型基于表现的功能评估包括哥伦比亚药物管理和圣地亚哥财务测试。这些新型的功能表现评估用于预测 HAND 的严重程度。两项客观的功能表现测量，哥伦比亚药物管理量表和圣地亚哥财务测试，均与 HAND 的严重程度相关。Karnofsky 表现量表和角色及身体生活质量问卷是与 HAND 特定程度相关的主观测量。新型功能表现评估可以用于客观评估 HAND 中的功能障碍，并验证不同程度的 HAND。
