Gross Robert
Leonard Davis Institute of Health Economics, University of Pennsylvania, Philadelphia, PA.
LDI Issue Brief. 2007 Nov-Dec;13(2):1-4.
Antiretroviral therapy is complicated and can be hard to follow. For HIV-infected patients, adhering to a prescribed regimen of antiretroviral therapy provides important individual survival benefits, and also reduces the risk of developing drug resistant viral strains that can infect others. Even patients with initially high levels of adherence to antiretroviral therapy face the challenge of maintaining those levels over time. Ideally, clinicians caring for HIV-infected patients would have some way of predicting which patients are most likely to need help in adhering to a prescribed regimen and an early warning system alerting them to their patients' non-adherence. This Issue Brief summarizes recent studies whose findings may help clinicians predict and monitor their patients' adherence before treatment failure occurs.
抗逆转录病毒疗法很复杂，可能难以遵循。对于感染艾滋病毒的患者来说，坚持规定的抗逆转录病毒治疗方案不仅能为个体带来重要的生存益处，还能降低产生可感染他人的耐药病毒株的风险。即使是最初对抗逆转录病毒疗法依从性较高的患者，也面临着长期维持这些依从水平的挑战。理想情况下，照顾感染艾滋病毒患者的临床医生应该有某种方法来预测哪些患者最有可能在坚持规定治疗方案方面需要帮助，并有一个早期预警系统来提醒他们注意患者的不依从情况。本问题简报总结了近期的研究，其研究结果可能有助于临床医生在治疗失败发生前预测和监测患者的依从性。
