强效丙型肝炎核心二聚体抑制剂：抗丙型肝炎药物的新先导物。
Potent inhibitors of hepatitis C core dimerization as new leads for anti-hepatitis C agents.
机构信息
Department of Chemistry and the Center for Chemical Methodology and Library Development, Boston University, 590 Commonwealth Ave, Boston, MA 02215, United States.
出版信息
Bioorg Med Chem Lett. 2011 Apr 15;21(8):2198-202. doi: 10.1016/j.bmcl.2011.03.014.
New indoline alkaloid-type compounds which inhibit HCV production by infected hepatoma cells have been identified. These compounds, dimeric-type compounds of previously known inhibitors, display double digit nanomolar IC(50) and EC(50) values, with cytotoxicity CC(50) indexes higher than 36 μM, thus providing ample therapeutic windows for further development of HCV drugs.
已鉴定出可抑制受感染肝癌细胞中 HCV 产生的新型吲哚啉生物碱类化合物。这些化合物为先前已知抑制剂的二聚体类型化合物，显示出双位数纳摩尔 IC(50)和 EC(50)值，细胞毒性 CC(50)指数高于 36 μM，从而为 HCV 药物的进一步开发提供了充足的治疗窗口。
Zotero 插件