扩张素，一种来自……内生真菌的新型吲哚生物碱 - 麦角甾醇共轭物。 （原文句子不完整，翻译可能会稍显突兀）
Expansinine, a novel indole alkaloid-ergosteroid conjugate from the endophytic fungus of .
作者信息
Li Chenzhe, He Ziruo, Wen Zhaofei, Sun Guangqian, Tang Xianying, Yin Tianpeng, Cai Le
机构信息
Key Laboratory of Medicinal Chemistry for Natural Resource, Ministry of Education, Yunnan Characteristic Plant Extraction Laboratory, Institute of International Rivers and Eco-security, School of Chemical Science and Technology, Yunnan University Kunming 650091 P. R. China
School of Bioengineering, Zunyi Medical University Zhuhai 519041 China
出版信息
RSC Adv. 2025 May 2;15(18):14283-14288. doi: 10.1039/d5ra02287h. eCollection 2025 Apr 28.
The endophytic fungus WTJP1 was isolated from Debeaux, a famous traditional Chinese medicine known as aconite. Chemical investigation of this aconite-derived fungus led to the isolation of one previously undescribed compound, expansinine (1), which represents the first example of an indole alkaloid-ergosteroid conjugate found in nature. The assignments of the structure of 1 were determined by extensive spectroscopic and spectrometric ECD and DP4+ probability analyses. In addition, compound 1 was evaluated for its cytotoxic activities against five human cancer cell lines.
内生真菌WTJP1是从著名的传统中药乌头中分离得到的。对这种源自乌头的真菌进行化学研究，分离出了一种此前未被描述的化合物——伸展宁（1），它是自然界中发现的首个吲哚生物碱-麦角甾醇共轭物实例。通过广泛的光谱分析、光谱ECD和DP4 +概率分析确定了1的结构归属。此外，还评估了化合物1对五种人类癌细胞系的细胞毒性活性。
Zotero 插件