Venning C M, Curtis M A, Egerton J R
Department of Animal Health, University of Sydney, Camden, New South Wales.
Aust Vet J. 1990 Jul;67(7):258-60. doi: 10.1111/j.1751-0813.1990.tb07781.x.
A mixture of lincomycin and spectinomycin was investigated as a treatment for footrot in sheep. In a controlled clinical trial 92.5% of acute and chronic cases of virulent footrot were cured following a single intramuscular injection of a mixture containing 50 mg lincomycin and 100 mg spectinomycin/ml at a dose rate of 1 ml/10 kg bodyweight. No improvement in clinical response was observed in groups of sheep treated on 3 successive days with this dose rate nor in another group treated once at a dose rate 1 ml/3.3 kg bodyweight. Cure effectiveness of each of the 3 treatment groups relative to untreated controls was 89%, 95% and 95%. Efficacy of lincomycin/spectinomycin was compared with that of penicillin/streptomycin in the treatment of footrot on 2 farms in south western New South Wales. Assessments made 14 to 17 d after treatment showed that on one farm all 122 ewes treated with lincomycin/spectinomycin had recovered while 170 of 175 ewes treated with penicillin/streptomycin recovered in the same period. On the second farm 87 of 90 ewes treated with lincomycin/spectinomycin recovered, compared with 184 of 190 sheep in the same flock treated with penicillin/streptomycin. Supportive footbathing did not seem to improve the clinical response in either treatment group and the paring done was sufficient only to establish diagnosis and to remove grossly overgrown horn.
对林可霉素和壮观霉素的混合物进行了研究，以用于治疗绵羊的腐蹄病。在一项对照临床试验中，对患有急性和慢性恶性腐蹄病的病例，按1毫升/10千克体重的剂量率单次肌内注射含50毫克林可霉素和100毫克壮观霉素/毫升的混合物后，92.5%的病例得到治愈。以该剂量率连续3天对绵羊进行治疗的组，以及以1毫升/3.3千克体重的剂量率进行单次治疗的另一组绵羊，均未观察到临床反应有改善。3个治疗组相对于未治疗对照组的治愈率分别为89%、95%和95%。在新南威尔士州西南部的2个农场，对林可霉素/壮观霉素与青霉素/链霉素治疗腐蹄病的效果进行了比较。治疗后14至17天进行的评估显示，在一个农场，用林可霉素/壮观霉素治疗的所有122只母羊均已康复，而同期用青霉素/链霉素治疗的175只母羊中有170只康复。在第二个农场，用林可霉素/壮观霉素治疗的90只母羊中有87只康复，而在同一羊群中用青霉素/链霉素治疗的190只羊中有184只康复。辅助性足部药浴似乎并未改善任何一个治疗组的临床反应，所进行的蹄部修剪仅足以确诊并去除过度生长的蹄角质。
