Department of Epidemiology and Biostatistics, EMGO/Longitudinal Aging Study Amsterdam, VU University Medical Centre, Van der Boechorststraat 7, 1081 BT Amsterdam, The Netherlands.
J Gerontol B Psychol Sci Soc Sci. 2011 May;66(3):380-6. doi: 10.1093/geronb/gbr032. Epub 2011 Mar 25.
Chronic diseases are important predictors of self-rated health (SRH). This study investigated whether multimorbidity has a synergistic or cumulative impact on SRH. Moderation by gender and age was examined.
Data originated from the Longitudinal Aging Study Amsterdam (N=2046, aged 57-98 years). We assessed the presence of lung disease, cardiac disease, peripheral atherosclerosis, stroke, diabetes mellitus, arthritis, and cancer. SRH was measured with the question "How is your health in general?" including 5 response categories. Generalized ordered probit models were applied; possible synergism was examined by testing for nonlinearity of the association.
The association between multimorbidity and SRH was nonlinear in that the effect of having a single disease was larger than the added effects of co-occurring diseases. However, from the second disease onward, each additional co-occurring disease caused cumulative declines in SRH. Only in the oldest old (85+), the impact of a single disease was similar to that of co-occurring diseases. Results were similar for men and women.
Our findings help to improve understanding of the impact multimorbidity has on SRH: Having a single disease increases the chance of poor health more than each co-occurring disease, indicating some overlap between diseases or adaptation to declining health.
慢性病是自评健康(SRH)的重要预测因素。本研究探讨了多种疾病是否对 SRH 具有协同或累积影响。并检验了性别和年龄的调节作用。
数据来自阿姆斯特丹纵向老龄化研究(N=2046,年龄 57-98 岁)。我们评估了肺部疾病、心脏疾病、外周动脉粥样硬化、中风、糖尿病、关节炎和癌症的存在情况。SRH 通过“总体而言,您的健康状况如何?”这个问题来衡量,其中包括 5 个回答类别。应用广义有序概率模型;通过测试关联的非线性来检验协同作用的存在。
多种疾病与 SRH 之间的关联是非线性的,即患有单一疾病的影响大于同时发生的疾病的附加影响。然而,从第二种疾病开始,每增加一种共同发生的疾病都会导致 SRH 的累积下降。只有在最年长的老年人(85 岁及以上)中,单一疾病的影响与共同发生的疾病相似。男性和女性的结果相似。
我们的研究结果有助于提高对多种疾病对 SRH 影响的理解:患有单一疾病会增加健康状况不佳的可能性,超过每种共同发生的疾病,这表明疾病之间存在一些重叠或对健康下降的适应。