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A molecular switch of "yin and yang": S-glutathionylation of eNOS turns off NO synthesis and turns on superoxide generation.

作者信息

Duan Dayue Darrel, Kwan Chiu-yin

机构信息

The Laboratory of Cardiovascular Phenomics, Center of Biomedical Research Excellence, and the Department of Pharmacology, University of Nevada School of Medicine, Reno, NV 89557, USA.

出版信息

Acta Pharmacol Sin. 2011 Apr;32(4):415-6. doi: 10.1038/aps.2011.21. Epub 2011 Mar 28.

DOI:10.1038/aps.2011.21
PMID:21441949
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4001984/
Abstract
摘要

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1
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Nature. 2010 Dec 23;468(7327):1115-8. doi: 10.1038/nature09599.
2
Tetrahydrobiopterin, superoxide, and vascular dysfunction.四氢生物蝶呤、超氧阴离子自由基和血管功能障碍。
Free Radic Biol Med. 2009 Oct 15;47(8):1108-19. doi: 10.1016/j.freeradbiomed.2009.07.024. Epub 2009 Jul 21.
3
Molecular mechanisms and clinical implications of reversible protein S-glutathionylation.可逆性蛋白质S-谷胱甘肽化修饰的分子机制及临床意义
Antioxid Redox Signal. 2008 Nov;10(11):1941-88. doi: 10.1089/ars.2008.2089.
4
Nitric oxide and peroxynitrite in health and disease.一氧化氮与过氧亚硝酸盐在健康与疾病中的作用
Physiol Rev. 2007 Jan;87(1):315-424. doi: 10.1152/physrev.00029.2006.
5
Nitric oxide, human diseases and the herbal products that affect the nitric oxide signalling pathway.一氧化氮、人类疾病以及影响一氧化氮信号通路的草药产品。
Clin Exp Pharmacol Physiol. 2003 Sep;30(9):605-15. doi: 10.1046/j.1440-1681.2003.03885.x.
6
Endothelial dysfunction in cardiovascular diseases: the role of oxidant stress.心血管疾病中的内皮功能障碍：氧化应激的作用
Circ Res. 2000 Nov 10;87(10):840-4. doi: 10.1161/01.res.87.10.840.
7
Endothelium-derived relaxing factor: discovery, early studies, and identification as nitric oxide.内皮源性舒张因子：发现、早期研究以及一氧化氮的鉴定
Biosci Rep. 1999 Aug;19(4):235-51. doi: 10.1023/a:1020537506008.
8
Nitric oxide signaling: would you believe that a simple free radical could be a second messenger, autacoid, paracrine substance, neurotransmitter, and hormone?一氧化氮信号传导：你能相信一种简单的自由基可以作为第二信使、自分泌物质、旁分泌物质、神经递质和激素吗？
Recent Prog Horm Res. 1998;53:43-59; discussion 59-60.
9
Nitric oxide synthase generates superoxide and nitric oxide in arginine-depleted cells leading to peroxynitrite-mediated cellular injury.一氧化氮合酶在精氨酸耗竭的细胞中产生超氧化物和一氧化氮，导致过氧亚硝酸盐介导的细胞损伤。
Proc Natl Acad Sci U S A. 1996 Jun 25;93(13):6770-4. doi: 10.1073/pnas.93.13.6770.
10
Nitric oxide synthases: gene structure and regulation.
Adv Pharmacol. 1995;34:71-90. doi: 10.1016/s1054-3589(08)61081-9.