信号转导与转录激活因子3、E-钙黏蛋白和波形蛋白在结肠癌中的临床意义

[Clinical significance of signal transduction and activators of transcription 3, E-cadherin and vimentin in colon cancer].

作者信息

Zhang Chao, Xu Jian-Hua, Liu Tao, Cui Hao

机构信息

Department of General Surgery, Southwest Hospital, The Third Military Medical University, Chongqing 400038, China.

出版信息

Zhonghua Wei Chang Wai Ke Za Zhi. 2011 Mar;14(3):202-5.

PMID:21442485

Abstract

OBJECTIVE

To evaluate the clinical significance of STAT3, E-cadherin and vimentin in colon cancer.

METHODS

Samples of colon cancer tissue and adjacent normal tissue were procured from 70 patients with colon cancer. The expressions of STAT3, E-cadherin and vimentin were detected by immunohistochemistry. Associations of clinicopathological characteristics and these three factors were evaluated.

RESULTS

STAT3, E-cadherin, vimentin were positive in 74.3%,32.9%, and 78.6% in the colon cancer tissues, respectively, and were 15.7%, 82.9%, and 12.9% in normal colon mucosa tissues, respectively. They were correlated with tumor differentiation, depth of invasion, lymph node metastasis, and TNM staging(P<0.05). There was a positive correlation between STAT3 and vimentin expression(P<0.01). However, STAT3 was negatively correlated with E-cadherin(P<0.01).

CONCLUSIONS

STAT3, E-cadherin and vimentin are closely associated with colon cancer. The expressions of STAT3, E-cadherin and vimentin may serve as prognostic indicators for patients with colon cancer.

摘要

目的

评估信号转导与转录激活因子3（STAT3）、E-钙黏蛋白和波形蛋白在结肠癌中的临床意义。

方法

从70例结肠癌患者中获取癌组织及癌旁正常组织样本。采用免疫组织化学法检测STAT3、E-钙黏蛋白和波形蛋白的表达情况。评估临床病理特征与这三个因素之间的相关性。

结果

STAT3、E-钙黏蛋白、波形蛋白在结肠癌组织中的阳性表达率分别为74.3%、32.9%、78.6%，在正常结肠黏膜组织中的阳性表达率分别为15.7%、82.9%、12.9%。它们与肿瘤分化程度、浸润深度、淋巴结转移及TNM分期相关（P<0.05）。STAT3与波形蛋白的表达呈正相关（P<0.01）。然而，STAT3与E-钙黏蛋白呈负相关（P<0.01）。