Kamp-Becker Inge, Schröder Johanna, Muehlan Holger, Remschmidt Helmut, Becker Katja, Bachmann Christian J
Department of Child and Adolescent Psychiatry, University Hospital Gießen and Marburg, Campus Marburg, Germany.
Z Kinder Jugendpsychiatr Psychother. 2011 Mar;39(2):123-31. doi: 10.1024/1422-4917/a000098.
This study evaluates self- and proxy-reported health-related quality of life (HRQOL) in children and adolescents with autism spectrum disorders (ASD). The study also compares HRQOL in ASD patients with a healthy control sample and a psychiatric reference sample.
42 children and adolescents (39 male, mean age: 12.7 ± 2.6 years, mean IQ: 100.5 ± 20.7) with the diagnosis of autism spectrum disorder (ASD) and their parents completed the Inventory for the Assessment of Quality of Life in Children and Adolescents (ILK).
Mean ILK LQ 0-28 scores were 20.6 (± 4.6) (self-report version) and 18.2 (± 4.0) (proxy version). Compared to a reference sample, mean ILK scores from the ASD sample were at the 47th percentile (self-report) and the 33rd percentile (proxy). Compared to children and adolescents with psychiatric disorders, self-reported ILK scores correlated with the 69th percentile, and proxy-reported ILK scores correlated with the 67th percentile. Self-reported HRQOL was significantly higher than proxy-reported HRQOL. No significant correlation was found between HRQOL and age, IQ, or autistic symptoms.
HRQOL in children and adolescents with ASD seems to be better than in other psychiatric disorders, but lower than in healthy controls.
本研究评估自闭症谱系障碍（ASD）儿童和青少年自我报告及代理报告的健康相关生活质量（HRQOL）。该研究还比较了ASD患者与健康对照样本及精神科参考样本的HRQOL。
42名被诊断为自闭症谱系障碍（ASD）的儿童和青少年（39名男性，平均年龄：12.7±2.6岁，平均智商：100.5±20.7）及其父母完成了儿童和青少年生活质量评估量表（ILK）。
ILK LQ 0 - 28量表的平均得分，自我报告版本为20.6（±4.6），代理报告版本为18.2（±4.0）。与参考样本相比，ASD样本的ILK平均得分处于第47百分位（自我报告）和第33百分位（代理报告）。与患有精神疾病的儿童和青少年相比，自我报告的ILK得分与第69百分位相关，代理报告的ILK得分与第67百分位相关。自我报告的HRQOL显著高于代理报告的HRQOL。未发现HRQOL与年龄、智商或自闭症症状之间存在显著相关性。
ASD儿童和青少年的HRQOL似乎优于其他精神疾病患者，但低于健康对照组。
