在雌性大鼠饮食中添加玉米油对其心脏、肝脏和肾脏能量代谢的影响。

Effects of corn oil addition to the diet on the energy metabolism of heart, liver and kidney of female rats.

作者信息

Bachmann E, Weber E

机构信息

Institute of Toxicology, Swiss Federal Institute of Technology, Schwerzenbach, Schweiz.

出版信息

Pharmacol Toxicol. 1990 Jul;67(1):49-55. doi: 10.1111/j.1600-0773.1990.tb00781.x.

DOI:10.1111/j.1600-0773.1990.tb00781.x

PMID:2144346

Abstract

Female rats (SIV-50, Sprague Dawley) given a diet enriched with corn oil (10% and 25% addition to rat chow, w/w) for four weeks showed changes in the energy metabolism of heart, liver and kidneys, that is, changes in oxygen consumption and uncoupling of oxidative phosphorylation of heart, liver and kidney mitochondria, concomitant to a decrease in heart mitochondrial creatine kinase activity and an increase in heart mitochondrial creatine content. The high fat diet also affected calcium binding and Na/K-, Mg- and Ca-ATPases of a cardiac myocyte membrane fraction. Lipid feeding also led to increase (biphasic and transient) of phospholipids, triglycerides and free fatty acids in the three organs studied, but in no case to hypertrophy.

摘要

给雌性大鼠（SIV - 50，斯普拉格 - 道利大鼠）喂食富含玉米油的饲料（占大鼠饲料的10%和25%，重量/重量）四周后，其心脏、肝脏和肾脏的能量代谢出现变化，即心脏、肝脏和肾脏线粒体的耗氧量和氧化磷酸化解偶联发生变化，同时心脏线粒体肌酸激酶活性降低，心脏线粒体肌酸含量增加。高脂饮食还影响心肌细胞膜部分的钙结合以及钠/钾 - 、镁 - 和钙 - ATP酶。脂质喂养还导致所研究的三个器官中的磷脂、甘油三酯和游离脂肪酸增加（双相且短暂），但在任何情况下均未导致肥大。